General Information of Drug (ID: DMMF0OP)

Drug Name
RO-4987655 Drug Info
Synonyms CH-4987655; RO-04927350; MEK inhibitors (solid tumor), Roche
Cross-matching ID
PubChem CID
11548630
ChEBI ID
CHEMBL1614766
CAS Number
CAS 874101-00-5
TTD Drug ID
D09GHB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.19 0.00e+0 93/133 (69.92%) ATP5PD;ATP6V0E1;LHPP;...
Valine, leucine and isoleucine degradation 2.12 0.00e+0 42/48 (87.5%) ABAT;HMGCS1;HMGCL;...
Lysosome 2.10 0.00e+0 115/128 (89.84%) TPP1;NPC2;PSAP;...
Necroptosis 1.94 7.30e-3 113/159 (71.07%) CAPN1;TNFSF10;IRF9;...
Other glycan degradation 1.88 8.76e-3 13/18 (72.22%) FUCA1;NEU1;MAN2B2;...
Metabolism of xenobiotics by cytochrome P450 1.88 7.30e-3 49/77 (63.64%) MGST3;ALDH3B1;GSTK1;...
Peroxisome 1.87 1.04e-2 72/82 (87.8%) PHYH;GSTK1;IDH1;...
Histidine metabolism 1.86 9.13e-3 16/22 (72.73%) ALDH3B1;MAOA;ALDH2;...
Coronavirus disease 1.80 1.14e-2 215/232 (92.67%) CFB;MX1;ISG15;...
Graft-versus-host disease 1.79 1.02e-2 32/42 (76.19%) HLA-B;HLA-F;HLA-E;...
Cell adhesion molecules 1.78 1.19e-2 118/148 (79.73%) HLA-B;VTCN1;HLA-F;...
Tryptophan metabolism 1.78 1.10e-2 35/42 (83.33%) MAOA;CAT;CYP1A1;...
Shigellosis 1.75 2.02e-2 180/246 (73.17%) CAPN1;FOXO4;NFKBIA;...
Fatty acid degradation 1.74 1.88e-2 40/43 (93.02%) ALDH2;ALDH3A2;ADH1B;...
Herpes simplex virus 1 infection 1.74 1.95e-2 165/498 (33.13%) IRF9;STAT1;IFIH1;...
Cardiac muscle contraction 1.73 2.01e-2 64/87 (73.56%) TPM1;TPM2;TNNC1;...
Platelet activation 1.73 1.98e-2 106/124 (85.48%) MYLK;RASGRP1;ADCY9;...
ABC transporters 1.72 2.03e-2 37/45 (82.22%) DEFB1;TAP1;ABCG1;...
Butanoate metabolism 1.72 2.15e-2 23/28 (82.14%) ABAT;HMGCS1;HMGCL;...
Influenza A 1.71 2.04e-2 156/172 (90.7%) MX1;TNFSF10;IRF9;...
beta-Alanine metabolism 1.71 2.36e-2 25/30 (83.33%) ABAT;ALDH3B1;ALDH6A1;...
Allograft rejection 1.69 2.85e-2 32/38 (84.21%) HLA-B;HLA-F;HLA-E;...
Steroid biosynthesis 1.69 2.79e-2 19/20 (95%) TM7SF2;LSS;LIPA;...
Tight junction 1.66 3.16e-2 130/169 (76.92%) ERBB2;MYL9;TUBA1A;...
Hepatitis C 1.66 3.10e-2 139/157 (88.54%) MX1;IFIT1;IRF9;...
Endocrine and other factor-regulated calcium reabsorpti... 1.66 3.09e-2 49/53 (92.45%) ATP2B4;ADCY9;ATP1B1;...
NOD-like receptor signaling pathway 1.66 2.98e-2 145/181 (80.11%) TXNIP;IRF9;STAT1;...
Th1 and Th2 cell differentiation 1.66 2.92e-2 80/92 (86.96%) MAF;STAT1;NFKBIA;...
Antigen processing and presentation 1.66 2.92e-2 60/78 (76.92%) HLA-B;TAPBP;CTSS;...
Propanoate metabolism 1.64 3.51e-2 30/34 (88.24%) ABAT;ALDH6A1;DLD;...
mRNA surveillance pathway -1.60 2.99e-2 71/98 (72.45%) DDX19A;CPSF6;PPP2R5D;...
Proteasome -1.64 2.30e-2 44/46 (95.65%) PSMD6;PSMF1;PSMB3;...
Non-homologous end-joining -1.64 2.32e-2 11/13 (84.62%) POLM;XRCC5;MRE11;...
Nucleotide excision repair -1.73 8.64e-3 40/47 (85.11%) RAD23A;RFC2;CCNH;...
One carbon pool by folate -1.79 5.12e-3 15/20 (75%) MTHFD2L;GART;DHFR;...
RNA polymerase -1.80 5.48e-3 23/31 (74.19%) POLR3E;POLR3D;POLR3C;...
Cysteine and methionine metabolism -1.83 5.51e-3 43/50 (86%) GCLC;TAT;GOT2;...
Homologous recombination -1.84 5.54e-3 35/41 (85.37%) RPA1;SSBP1;BARD1;...
Progesterone-mediated oocyte maturation -1.86 2.79e-3 75/100 (75%) MAD1L1;MAPK9;ADCY2;...
Oocyte meiosis -1.88 2.56e-3 90/129 (69.77%) MAD1L1;SMC3;ADCY2;...
Base excision repair -1.90 2.27e-3 29/33 (87.88%) POLD3;LIG3;APEX2;...
Mismatch repair -2.00 6.40e-4 22/23 (95.65%) RFC2;MSH6;RPA3;...
Spliceosome -2.09 0.00e+0 101/150 (67.33%) LSM2;PUF60;SNRPB2;...
Fanconi anemia pathway -2.17 0.00e+0 36/54 (66.67%) TOP3A;FANCC;ATR;...
RNA transport -2.18 0.00e+0 128/186 (68.82%) PNN;NUP85;NMD3;...
Pyrimidine metabolism -2.19 0.00e+0 40/56 (71.43%) TK1;DCTPP1;ENPP1;...
Ribosome biogenesis in eukaryotes -2.28 0.00e+0 52/108 (48.15%) CSNK2A1;NXF3;REXO2;...
Cell cycle -2.60 0.00e+0 110/124 (88.71%) SMC1A;E2F2;CCND1;...
DNA replication -2.70 0.00e+0 34/36 (94.44%) RFC2;RNASEH1;RPA3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H