General Information of Drug (ID: DMMIAXO)

Drug Name
Betamethasone Valerate Drug Info
Synonyms Beta-val; Betaderm; Betatrex; Dermabet; Valnac
Cross-matching ID
PubChem CID
16533
ChEBI ID
CHEMBL31277
CAS Number
CAS 2152-44-5
TTD Drug ID
D03SXE
INTEDE Drug ID
DR2381

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.05 7.36e-3 84/94 (89.36%) IL1B;MMP9;CXCL6;...
Viral protein interaction with cytokine and cytokine re... 1.87 1.47e-2 84/100 (84%) CXCL14;CXCL6;CXCL2;...
Hepatocellular carcinoma -1.64 4.60e-2 135/168 (80.36%) ELK1;TXNRD1;EGFR;...
Colorectal cancer -1.68 3.22e-2 84/86 (97.67%) EGFR;BAK1;PIK3R3;...
Regulation of lipolysis in adipocytes -1.69 2.93e-2 52/55 (94.55%) ADCY1;ADRB3;PTGS1;...
Focal adhesion -1.69 3.01e-2 180/201 (89.55%) ILK;ACTB;PPP1R12A;...
Biosynthesis of unsaturated fatty acids -1.70 3.10e-2 21/27 (77.78%) BAAT;FADS2;ELOVL2;...
Th1 and Th2 cell differentiation -1.71 2.49e-2 80/92 (86.96%) STAT5A;MAPK14;NFATC3;...
Human T-cell leukemia virus 1 infection -1.74 1.89e-2 197/219 (89.95%) CDC16;XPO1;HLA-DOA;...
TGF-beta signaling pathway -1.75 1.86e-2 81/94 (86.17%) BAMBI;BMPR2;PPP2CA;...
Epstein-Barr virus infection -1.79 1.44e-2 189/202 (93.56%) NEDD4;CCND2;BAK1;...
Adherens junction -1.80 1.46e-2 63/71 (88.73%) ACTB;PTPRJ;PARD3;...
ECM-receptor interaction -1.80 1.56e-2 80/88 (90.91%) CD36;LAMC1;LAMC2;...
Asthma -1.81 1.49e-2 25/31 (80.65%) HLA-DOA;CD40LG;HLA-DQA1;...
Toxoplasmosis -1.82 1.32e-2 103/112 (91.96%) NFKBIB;PPIF;HLA-DOA;...
Ferroptosis -1.83 1.21e-2 36/41 (87.8%) MAP1LC3B;SLC39A8;NCOA4;...
Type I diabetes mellitus -1.83 1.34e-2 38/43 (88.37%) HLA-DQA1;HLA-DMB;IFNG;...
Ovarian steroidogenesis -1.85 1.21e-2 41/51 (80.39%) ADCY2;IGF1R;SCARB1;...
Phagosome -1.85 1.37e-2 118/152 (77.63%) ACTB;HLA-DOA;CD14;...
Hematopoietic cell lineage -1.90 8.67e-3 90/99 (90.91%) ITGAM;KIT;HLA-DOA;...
Leishmaniasis -1.92 1.01e-2 67/77 (87.01%) ITGAM;NFKBIB;HLA-DOA;...
Graft-versus-host disease -1.93 2.43e-3 32/42 (76.19%) HLA-DOA;CD80;KLRD1;...
Viral myocarditis -2.00 0.00e+0 53/60 (88.33%) ACTB;HLA-DOA;CD80;...
Autoimmune thyroid disease -2.32 0.00e+0 46/53 (86.79%) IFNA17;IL4;CD86;...
Allograft rejection -2.37 0.00e+0 32/38 (84.21%) IL4;CD86;IL2;...
Antigen processing and presentation -2.38 0.00e+0 60/78 (76.92%) NFYB;HLA-DQA1;HLA-DMB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H