Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMK42O)

Drug Name
Roquinimex Drug Info
Synonyms Linomide
Cross-matching ID
PubChem CID
54676478
ChEBI ID
CHEMBL11672
CAS Number
CAS 84088-42-6
TTD Drug ID
D0G9ZW
INTEDE Drug ID
DR1443

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.12 0.00e+0 34/36 (94.44%) PCNA;POLE2;PRIM1;...
Ribosome 2.02 0.00e+0 113/158 (71.52%) MRPL15;MRPL18;MRPL34;...
Ribosome biogenesis in eukaryotes 1.86 9.29e-3 52/108 (48.15%) IMP4;IMP3;NOP56;...
Malaria 1.85 8.36e-3 44/50 (88%) THBS2;CD40;COMP;...
Base excision repair 1.84 1.00e-2 29/33 (87.88%) PCNA;POLE2;FEN1;...
Spliceosome 1.77 1.67e-2 101/150 (67.33%) HSPA8;PRPF4;LSM5;...
Parkinson disease 1.75 1.75e-2 176/249 (70.68%) GNAI1;PPIF;CYCS;...
Proteasome 1.73 1.67e-2 44/46 (95.65%) PSMA6;PSMC3;PSMA2;...
Prion disease 1.73 1.55e-2 209/273 (76.56%) HSPA8;C7;MAPK13;...
Non-homologous end-joining 1.69 2.17e-2 11/13 (84.62%) DNTT;FEN1;MRE11;...
Mismatch repair 1.69 2.08e-2 22/23 (95.65%) PCNA;RFC4;RPA3;...
Homologous recombination 1.68 2.41e-2 35/41 (85.37%) RPA3;RBBP8;RAD54L;...
RNA polymerase 1.66 2.53e-2 23/31 (74.19%) POLR3K;POLR2L;POLR2I;...
Cell cycle 1.65 2.79e-2 110/124 (88.71%) CDC20;PCNA;SMC1A;...
Oocyte meiosis 1.60 4.31e-2 90/129 (69.77%) CDC20;SMC1A;MAPK13;...
AGE-RAGE signaling pathway in diabetic complications -1.66 3.90e-2 97/100 (97%) COL1A1;EDN1;PIK3CA;...
Galactose metabolism -1.66 4.03e-2 26/31 (83.87%) B4GALT1;LALBA;LCT;...
Adherens junction -1.66 4.02e-2 63/71 (88.73%) AFDN;CSNK2A1;FARP2;...
Insulin resistance -1.67 3.76e-2 96/108 (88.89%) IKBKB;MLXIP;PTPRF;...
Fc gamma R-mediated phagocytosis -1.68 3.85e-2 79/97 (81.44%) MAPK3;PLD1;PIP5K1C;...
Kaposi sarcoma-associated herpesvirus infection -1.68 4.00e-2 172/193 (89.12%) SRC;CASP9;PIK3CA;...
Choline metabolism in cancer -1.69 3.82e-2 84/98 (85.71%) PIK3CA;MAP2K2;KRAS;...
beta-Alanine metabolism -1.70 3.81e-2 25/30 (83.33%) ACOX1;ECHS1;EHHADH;...
Growth hormone synthesis, secretion and action -1.70 3.35e-2 108/119 (90.76%) PLCB1;MAP2K4;ADCY7;...
Arrhythmogenic right ventricular cardiomyopathy -1.71 2.85e-2 70/77 (90.91%) TCF7;ITGA4;CACNG3;...
VEGF signaling pathway -1.73 2.43e-2 50/59 (84.75%) SRC;CASP9;PIK3CA;...
Metabolism of xenobiotics by cytochrome P450 -1.74 2.34e-2 49/77 (63.64%) GSTA4;SULT2A1;CYP1A1;...
Sphingolipid metabolism -1.75 2.32e-2 32/49 (65.31%) B4GALT6;UGCG;PLPP3;...
Aldosterone-regulated sodium reabsorption -1.75 2.45e-2 34/37 (91.89%) SCNN1B;PIK3R1;ATP1B1;...
Pentose phosphate pathway -1.78 1.56e-2 25/30 (83.33%) PRPS1;PGD;H6PD;...
Insulin secretion -1.79 1.30e-2 75/86 (87.21%) ADCYAP1;PLCB1;CAMK2A;...
Carbohydrate digestion and absorption -1.79 1.39e-2 37/47 (78.72%) LCT;HK3;AKT2;...
Peroxisome -1.80 1.39e-2 72/82 (87.8%) PEX5;PEX19;ABCD4;...
Thyroid cancer -1.82 1.16e-2 36/37 (97.3%) DDB2;TCF7;CCND1;...
Fructose and mannose metabolism -1.82 1.26e-2 30/33 (90.91%) ALDOB;PFKM;ENOSF1;...
Rheumatoid arthritis -1.82 1.39e-2 78/93 (83.87%) ACP5;ITGAL;CSF1;...
Pentose and glucuronate interconversions -1.84 1.54e-2 17/34 (50%) UGT2B17;CRYL1;UGDH;...
ErbB signaling pathway -1.86 1.56e-2 79/85 (92.94%) EGFR;MAP2K4;CAMK2A;...
Bladder cancer -1.86 1.79e-2 40/41 (97.56%) SRC;MDM2;MAP2K2;...
Endometrial cancer -1.88 1.62e-2 56/58 (96.55%) DDB2;TCF7;CCND1;...
Thyroid hormone signaling pathway -1.90 1.39e-2 112/121 (92.56%) PIK3R1;ITGB3;ATP1B1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.95 3.48e-3 62/70 (88.57%) ATP6AP1;ATP6V0A1;ATP6V1E1;...
TNF signaling pathway -1.95 4.63e-3 103/112 (91.96%) TRADD;RELA;ATF2;...
GnRH secretion -2.07 0.00e+0 60/64 (93.75%) PLCB1;KCNJ6;GABBR2;...
IL-17 signaling pathway -2.15 0.00e+0 84/94 (89.36%) FOSB;MAPK14;JUN;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H