Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMML3J4)

Drug Name
NAN-190 Drug Info
Synonyms
NAN-190; Nan 190; NAN190; SJDOMIRMMUGQQK-UHFFFAOYSA-N; CHEMBL8618; CHEBI:64131; 2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione; 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; 2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione; 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione; 2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione; 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine
Cross-matching ID
PubChem CID
4431
ChEBI ID
CHEMBL8618
CAS Number
CAS 102392-05-2
TTD Drug ID
D0L9SN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Aldosterone-regulated sodium reabsorption 2.15 0.00e+0 34/37 (91.89%) MAPK1;SCNN1A;PIK3R1;...
Steroid biosynthesis 2.11 0.00e+0 19/20 (95%) TM7SF2;MSMO1;CYP51A1;...
Steroid hormone biosynthesis 1.96 4.07e-3 43/61 (70.49%) CYP1B1;UGT2B28;UGT2B17;...
Type I diabetes mellitus 1.80 4.58e-2 38/43 (88.37%) CPE;HLA-DPB1;HLA-DPA1;...
Protein processing in endoplasmic reticulum -1.61 4.20e-2 127/171 (74.27%) DNAJC1;SEC61G;PDIA3;...
Fructose and mannose metabolism -1.62 4.15e-2 30/33 (90.91%) HKDC1;FBP1;KHK;...
Mucin type O-glycan biosynthesis -1.68 2.43e-2 20/36 (55.56%) GALNT3;GALNT14;B3GNT3;...
Thyroid hormone synthesis -1.68 2.55e-2 66/75 (88%) FXYD2;PLCB4;ADCY8;...
Other types of O-glycan biosynthesis -1.68 2.75e-2 29/47 (61.7%) GALNT3;GALNT14;RFNG;...
Neomycin, kanamycin and gentamicin biosynthesis -1.69 2.79e-2 5/5 (100%) HKDC1;GCK;HK2
Proteasome -1.73 2.05e-2 44/46 (95.65%) POMP;PSMD1;PSMB2;...
Oxidative phosphorylation -1.74 1.97e-2 93/133 (69.92%) NDUFV1;NDUFB11;NDUFA8;...
Vasopressin-regulated water reabsorption -1.74 2.19e-2 40/44 (90.91%) RAB11B;GNAS;RAB5C;...
Ribosome biogenesis in eukaryotes -1.74 2.37e-2 52/108 (48.15%) GAR1;IMP3;RCL1;...
Glycosaminoglycan biosynthesis -1.79 1.35e-2 40/58 (68.97%) CHST7;CHPF;EXTL2;...
N-Glycan biosynthesis -1.84 4.86e-3 38/50 (76%) MAN2A2;MOGS;MAN1A2;...
Protein export -1.89 4.37e-3 17/23 (73.91%) SPCS1;SEC62;SRP14;...
Parkinson disease -1.90 5.47e-3 176/249 (70.68%) NDUFV1;CALML4;NDUFB11;...
Vibrio cholerae infection -1.91 7.29e-3 44/50 (88%) PDIA4;KDELR2;ATP6AP1;...
Glycine, serine and threonine metabolism -1.92 1.09e-2 31/40 (77.5%) ALDH7A1;BHMT;PIPOX;...
Various types of N-glycan biosynthesis -1.93 2.19e-2 26/39 (66.67%) MAN1A1;MAN2A2;MAN1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H