Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMN36E)

• Drug Name: Abacavir Drug Info
• Synonyms: Trizivir; Ziagen; Abacavir [INN]; Abacavir (INN); Ziagen (TN); Ziagen (TM)(*Succinate salt*); [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol; {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol; (+/-)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (+/-)-Abacavir; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ABC
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 441300
  ChEBI ID: CHEMBL1380
  CAS Number: CAS 136470-78-5
  TTD Drug ID: D0A4IJ
  VARIDT Drug ID: DR00588
  INTEDE Drug ID: DR0027
  ACDINA Drug ID: D00002

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Intestinal immune network for IgA production	2.21	0.00e+0	38/48 (79.17%)	CD40;HLA-DPA1;HLA-DQB1;...
Tryptophan metabolism	2.10	0.00e+0	35/42 (83.33%)	ALDH2;KYNU;DLD;...
Allograft rejection	2.08	4.40e-3	32/38 (84.21%)	CD40;HLA-DPA1;HLA-DQB1;...
Pentose phosphate pathway	2.05	6.60e-3	25/30 (83.33%)	PFKL;DERA;G6PD;...
Asthma	2.05	5.28e-3	25/31 (80.65%)	CD40;HLA-DPA1;HLA-DQB1;...
Autoimmune thyroid disease	2.04	4.40e-3	46/53 (86.79%)	CD40;HLA-DPA1;HLA-DQB1;...
Graft-versus-host disease	1.94	7.55e-3	32/42 (76.19%)	HLA-DPA1;HLA-DQB1;HLA-DMB;...
Valine, leucine and isoleucine degradation	1.89	1.16e-2	42/48 (87.5%)	ALDH2;HMGCS1;DLD;...
Systemic lupus erythematosus	1.87	1.03e-2	45/135 (33.33%)	CD40;HLA-DPA1;HLA-DQB1;...
Citrate cycle (TCA cycle)	1.82	1.98e-2	30/30 (100%)	DLD;IDH2;CS;...
Carbohydrate digestion and absorption	1.81	2.04e-2	37/47 (78.72%)	SLC37A4;PLCB1;FXYD2;...
Salivary secretion	1.81	1.87e-2	76/93 (81.72%)	PLCB1;FXYD2;PRKACB;...
beta-Alanine metabolism	1.74	3.05e-2	25/30 (83.33%)	ALDH2;ALDH3A2;ALDH3A1;...
Thyroid hormone signaling pathway	1.74	3.30e-2	112/121 (92.56%)	SRC;PFKL;BMP4;...
Type I diabetes mellitus	1.73	3.17e-2	38/43 (88.37%)	HLA-DPA1;HLA-DQB1;HLA-DMB;...
Glycolysis / Gluconeogenesis	1.73	3.14e-2	56/67 (83.58%)	ALDH2;DLD;PFKL;...
Th1 and Th2 cell differentiation	1.72	3.11e-2	80/92 (86.96%)	HLA-DPA1;HLA-DQB1;HLA-DMB;...
Histidine metabolism	1.69	4.18e-2	16/22 (72.73%)	ALDH2;ALDH3A2;ALDH3A1;...
Cortisol synthesis and secretion	1.68	4.31e-2	58/65 (89.23%)	NR4A1;PLCB1;PRKACB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼