Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMO3G5)

Drug Name
VS-5584 Drug Info
Synonyms
5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine; 1246560-33-7; VS-5584 (SB2343); UNII-W71J4X250V; SB-2343; SB2343; CHEMBL3393066; W71J4X250V; 5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine; C17H22N8O; QYBGBLQCOOISAR-UHFFFAOYSA-N; SCHEMBL539098; GTPL8382; EX-A288; DTXSID10677328; MolPort-035-757-944; HMS3652B16; BCP08247; 2797AH; ZINC95644685; s7016; VS5584; BDBM50059635; AKOS024465057; 5-(9-isopropyl-8-methyl-2-morpholin-4-yl-9H-purin-6-yl)-pyrimidin-2-ylamine; SB16877
Cross-matching ID
PubChem CID
46912230
ChEBI ID
CHEMBL3393066
CAS Number
CAS 1246560-33-7
TTD Drug ID
D0U3DP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.13 0.00e+0 80/88 (90.91%) CD44;LAMA4;FN1;...
Notch signaling pathway 1.90 8.61e-3 49/59 (83.05%) HEY1;TLE1;JAG1;...
Riboflavin metabolism -1.60 3.97e-2 7/8 (87.5%) ACP1;RFK;FLAD1;...
Thiamine metabolism -1.61 3.83e-2 12/15 (80%) ALPI;ALPG;AK2;...
Bacterial invasion of epithelial cells -1.62 3.80e-2 59/77 (76.62%) ILK;RAC1;PIK3R1;...
Tyrosine metabolism -1.63 3.30e-2 30/36 (83.33%) TYR;FAH;MIF;...
Phenylalanine metabolism -1.66 2.60e-2 14/17 (82.35%) GLYAT;MIF;HPD;...
Ferroptosis -1.67 2.56e-2 36/41 (87.8%) ACSL4;MAP1LC3B;FTL;...
Mineral absorption -1.67 2.67e-2 48/60 (80%) ATP2B3;SLC26A6;ATOX1;...
Spinocerebellar ataxia -1.69 2.14e-2 128/143 (89.51%) PIK3CB;PSMB7;PSMA1;...
Alanine, aspartate and glutamate metabolism -1.70 2.13e-2 27/37 (72.97%) GAD2;GLUL;ASS1;...
Pyruvate metabolism -1.70 2.12e-2 41/47 (87.23%) ACYP2;ALDH2;ALDH9A1;...
Oxidative phosphorylation -1.70 2.17e-2 93/133 (69.92%) COX8A;ATP6V1G1;COX6C;...
Citrate cycle (TCA cycle) -1.72 1.87e-2 30/30 (100%) OGDH;MDH1;DLD;...
Synthesis and degradation of ketone bodies -1.78 1.21e-2 9/10 (90%) ACAT2;HMGCS1
Arginine and proline metabolism -1.79 1.28e-2 39/50 (78%) ALDH2;LAP3;ALDH9A1;...
Folate biosynthesis -1.79 1.36e-2 23/26 (88.46%) ALPP;FPGS;SPR;...
Amyotrophic lateral sclerosis -1.80 1.14e-2 267/364 (73.35%) ATP5F1B;PFN1;SETX;...
Huntington disease -1.84 6.54e-3 233/306 (76.14%) MAPK9;BDNF;CLTB;...
Fructose and mannose metabolism -1.86 6.16e-3 30/33 (90.91%) PMM2;PFKFB4;HKDC1;...
Glycine, serine and threonine metabolism -1.96 9.53e-4 31/40 (77.5%) PIPOX;GLDC;DLD;...
Terpenoid backbone biosynthesis -1.98 1.04e-3 18/22 (81.82%) MVK;PDSS2;MVD;...
Cysteine and methionine metabolism -1.99 1.14e-3 43/50 (86%) BHMT2;GOT2;MDH1;...
Glutathione metabolism -2.06 1.27e-3 43/57 (75.44%) GGT1;GSR;SRM;...
Prion disease -2.07 1.43e-3 209/273 (76.56%) PIK3CB;PSMB7;PSMA1;...
Synaptic vesicle cycle -2.12 0.00e+0 63/78 (80.77%) SLC17A7;ATP6V1H;NSF;...
Glycolysis / Gluconeogenesis -2.12 0.00e+0 56/67 (83.58%) G6PC3;GCK;LDHC;...
Protein processing in endoplasmic reticulum -2.16 0.00e+0 127/171 (74.27%) HSPBP1;FBXO2;SKP1;...
Parkinson disease -2.22 0.00e+0 176/249 (70.68%) PSMB7;PSMA1;NFE2L2;...
Biosynthesis of unsaturated fatty acids -2.27 0.00e+0 21/27 (77.78%) SCP2;ELOVL5;TECR;...
Steroid biosynthesis -2.35 0.00e+0 19/20 (95%) SOAT1;TM7SF2;FDFT1;...
Proteasome -2.70 0.00e+0 44/46 (95.65%) PSMB7;PSMA1;PSME2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 2.5uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H