Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMQHOZ)

Drug Name
Oxyphenonium Drug Info
Synonyms
Argicillin; Atrenyl; Hydroxymethylgramicidin; Methacin; Methocidin; Methocidine; Methocidinum; Metocidina; Oxiphenonum; Spastrex;Oxyphenonium Chloride; Oxyphenonium Iodide; Methocidin [DCF:INN]; Methocidine [INN-French]; Methocidinum [INN-Latin]; Metocidina [INN-Spanish]; [2-(2-Cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-ethyl]-diethyl-methyl-ammonium; 2-((Cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methylethanaminium; 2-(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxyethyl-diethyl-methylazanium; 2-[2-cyclohexyl(hydroxy)phenylacetoxy]-n,n-diethyl-n-methylethanaminium
Therapeutic ClassParasympatholytics
Cross-matching ID
PubChem CID
5749
ChEBI ID
CHEMBL94329
CAS Number
CAS 14214-84-7
TTD Drug ID
D0D1MA
VARIDT Drug ID
DR01393

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Allograft rejection 1.92 2.11e-2 32/38 (84.21%) HLA-DRB1;GZMB;HLA-DMB;...
Viral myocarditis 1.90 1.06e-2 53/60 (88.33%) DMD;HLA-DRB1;ITGB2;...
Graft-versus-host disease 1.85 2.11e-2 32/42 (76.19%) HLA-DRB1;GZMB;HLA-DMB;...
Bacterial invasion of epithelial cells 1.84 1.58e-2 59/77 (76.62%) FN1;SRC;CDC42;...
Protein export 1.83 1.27e-2 17/23 (73.91%) SRP9;HSPA5;SPCS1;...
Vitamin digestion and absorption 1.83 1.06e-2 17/24 (70.83%) APOB;SLC5A6;ABCC1;...
Asthma 1.80 2.11e-2 25/31 (80.65%) RNASE3;HLA-DRB1;FCER1G;...
Focal adhesion 1.80 1.98e-2 180/201 (89.55%) COL1A2;FN1;FLT1;...
Antigen processing and presentation 1.75 3.29e-2 60/78 (76.92%) CD74;HLA-DRB1;CTSB;...
Proteoglycans in cancer 1.73 3.70e-2 172/205 (83.9%) COL1A2;FN1;MMP9;...
HIF-1 signaling pathway 1.69 4.99e-2 105/109 (96.33%) MKNK1;FLT1;TFRC;...
Platelet activation 1.69 4.84e-2 106/124 (85.48%) PLCB1;COL1A2;SRC;...
Autoimmune thyroid disease 1.68 4.88e-2 46/53 (86.79%) HLA-DRB1;GZMB;HLA-DMB;...
Viral protein interaction with cytokine and cytokine re... -1.99 0.00e+0 84/100 (84%) IL18RAP;TNFRSF1A;CXCR2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H