General Information of Drug (ID: DMMSDOY)

Drug Name
Stiripentol Drug Info
Synonyms Diacomit; ME-2080; Stiripentol (oral); Stiripentol (oral), Laboratoires Biocodex
Cross-matching ID
PubChem CID
5311454
ChEBI ID
CHEMBL94435
CAS Number
CAS 49763-96-4
TTD Drug ID
D02XSA
INTEDE Drug ID
DR1507
ACDINA Drug ID
D01440

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.66 5.08e-1 34/36 (94.44%) MCM2;FEN1;RFC2;...
Fatty acid biosynthesis 1.57 6.37e-1 16/18 (88.89%) FASN;ACSL3;ACACB;...
Glutathione metabolism 1.52 6.71e-1 43/57 (75.44%) RRM2;GPX3;MGST2;...
Regulation of lipolysis in adipocytes 1.48 6.82e-1 52/55 (94.55%) MGLL;ADCY1;PTGS2;...
Phenylalanine metabolism 1.47 6.30e-1 14/17 (82.35%) ALDH3A1;AOC3;MAOA;...
Platelet activation 1.21 6.96e-1 106/124 (85.48%) SRC;COL1A2;ADCY1;...
Hypertrophic cardiomyopathy 1.21 6.79e-1 81/90 (90%) DES;ACTC1;ATP2A2;...
Salivary secretion 1.21 6.65e-1 76/93 (81.72%) ADCY1;ITPR1;GUCY1A1;...
Amoebiasis 1.20 6.49e-1 99/102 (97.06%) COL1A2;COL4A5;ADCY1;...
Morphine addiction 1.19 6.64e-1 80/91 (87.91%) ADCY1;PRKCB;GNAS;...
Gap junction 1.18 6.92e-1 72/88 (81.82%) SRC;PDGFC;ADCY1;...
Protein processing in endoplasmic reticulum 1.18 6.86e-1 127/171 (74.27%) PDIA3;HSPA1A;HSPA8;...
Folate biosynthesis 1.18 6.73e-1 23/26 (88.46%) AKR1C3;GGH;AKR1B10;...
Arachidonic acid metabolism 1.17 6.66e-1 48/61 (78.69%) GPX3;PTGIS;GPX1;...
Estrogen signaling pathway 1.16 7.06e-1 119/137 (86.86%) KRT19;SRC;ADCY1;...
VEGF signaling pathway 1.16 6.92e-1 50/59 (84.75%) SRC;PTGS2;PRKCB;...
Chemical carcinogenesis 1.15 6.96e-1 186/281 (66.19%) SRC;EPHX1;MGST2;...
N-Glycan biosynthesis 1.15 7.01e-1 38/50 (76%) FUT8;MAN1A2;DDOST;...
Base excision repair 1.14 6.96e-1 29/33 (87.88%) FEN1;PCNA;NEIL3;...
Steroid biosynthesis 1.14 6.81e-1 19/20 (95%) NSDHL;DHCR24;SQLE
Progesterone-mediated oocyte maturation 1.14 6.71e-1 75/100 (75%) STK10;ADCY1;ADCY9;...
Measles 1.12 7.04e-1 133/139 (95.68%) IRAK1;IL2RB;CDK6;...
Diabetic cardiomyopathy 1.11 7.09e-1 162/203 (79.8%) COL1A2;GSR;ATP2A2;...
Drug metabolism 1.11 6.95e-1 78/151 (51.66%) RRM2;CES1;MGST2;...
Non-small cell lung cancer 1.11 6.82e-1 70/72 (97.22%) CDK6;RET;PRKCB;...
Spinocerebellar ataxia 1.11 6.71e-1 128/143 (89.51%) ATXN1;KCND3;RELN;...
Nucleotide excision repair 1.11 6.59e-1 40/47 (85.11%) MNAT1;RFC2;RFC5;...
Taurine and hypotaurine metabolism 1.10 6.65e-1 8/11 (72.73%) GAD1;ADO;GAD2;...
Thyroid hormone synthesis 1.09 6.89e-1 66/75 (88%) GPX3;ADCY1;ITPR1;...
Herpes simplex virus 1 infection 1.09 7.06e-1 165/498 (33.13%) BST2;SRC;IRAK1;...
Arginine biosynthesis -1.36 3.51e-1 17/22 (77.27%) GLS;GLUD2;GOT1;...
B cell receptor signaling pathway -1.37 3.34e-1 71/81 (87.65%) PPP3CC;LILRA1;RELA;...
NF-kappa B signaling pathway -1.37 3.43e-1 90/104 (86.54%) BIRC3;CSNK2B;CXCL3;...
Acute myeloid leukemia -1.37 3.54e-1 66/67 (98.51%) RUNX1;KRAS;JUP;...
mTOR signaling pathway -1.38 3.53e-1 114/154 (74.03%) MAPK1;DDIT4;FZD3;...
Apoptosis -1.40 3.19e-1 126/168 (75%) PMAIP1;GADD45G;CTSL;...
Sphingolipid metabolism -1.41 3.21e-1 32/49 (65.31%) GAL3ST1;NEU1;GALC;...
Synthesis and degradation of ketone bodies -1.42 3.13e-1 9/10 (90%) HMGCL;OXCT1;HMGCS1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.42 3.11e-1 62/70 (88.57%) PTPRZ1;ADAM17;JUN;...
Thyroid cancer -1.44 2.69e-1 36/37 (97.3%) TFG;GADD45G;TPR;...
AGE-RAGE signaling pathway in diabetic complications -1.45 2.79e-1 97/100 (97%) NRAS;ICAM1;EGR1;...
Bile secretion -1.45 2.83e-1 68/90 (75.56%) AQP1;ABCB4;SLC10A2;...
Th1 and Th2 cell differentiation -1.46 2.73e-1 80/92 (86.96%) JAK1;IL4;PPP3CC;...
Phagosome -1.47 2.77e-1 118/152 (77.63%) TUBB1;ITGA2;SCARB1;...
Vasopressin-regulated water reabsorption -1.47 2.94e-1 40/44 (90.91%) CREB5;CREB1;DCTN5;...
Malaria -1.49 2.65e-1 44/50 (88%) MET;IL1B;THBS1;...
MicroRNAs in cancer -1.50 2.45e-1 146/310 (47.1%) MAPK1;ROCK1;CDKN1A;...
Cholesterol metabolism -1.54 2.07e-1 44/50 (88%) LPA;LIPC;APOA1;...
SNARE interactions in vesicular transport -1.54 2.10e-1 19/33 (57.58%) BET1;STX4;STX1A;...
PPAR signaling pathway -1.54 2.28e-1 66/74 (89.19%) ACADL;APOA2;FABP7;...
Salmonella infection -1.56 2.19e-1 198/249 (79.52%) HSP90AA1;ACTR3;TXN;...
Alanine, aspartate and glutamate metabolism -1.59 1.79e-1 27/37 (72.97%) ALDH4A1;GFPT2;GLS;...
Nitrogen metabolism -1.60 1.90e-1 16/17 (94.12%) CA3;GLUD2;GLUD1;...
African trypanosomiasis -1.60 2.00e-1 32/37 (86.49%) HPR;IL12B;ICAM1;...
Hematopoietic cell lineage -1.61 2.33e-1 90/99 (90.91%) ITGA2;ANPEP;IL7;...
Complement and coagulation cascades -1.65 1.87e-1 76/85 (89.41%) C6;F7;C1QB;...
Primary immunodeficiency -1.67 1.80e-1 33/38 (86.84%) PTPRC;CD79A;ICOS;...
Nicotinate and nicotinamide metabolism -1.71 1.47e-1 25/35 (71.43%) BST1;SIRT5;AOX1;...
TGF-beta signaling pathway -1.74 1.52e-1 81/94 (86.17%) PPP2R1A;HAMP;CUL1;...
Proximal tubule bicarbonate reclamation -1.76 2.26e-1 21/23 (91.3%) PCK2;GLS2;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H