Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMT1YQ)

• Drug Name: Bropirimine Drug Info
• Synonyms: 56741-95-8; 2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine; ABPP; 2-AMINO-5-BROMO-6-PHENYLPYRIMIDIN-4-OL; Bropiriminum [Latin]; 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidinone; 2-amino-5-bromo-6-phenylpyrimidin-4(3H)-one; U-54461; Bropirimina [Spanish]; UNII-J57CTF25XJ; C10H8BrN3O; CCRIS 3730; 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one; 2-Amino-5-bromo-6-phenyl-4(1H)-pyrimidinone; 4(1H)-Pyrimidinone, 2-amino-5-bromo-6-phenyl-; BRN 0651807; J57CTF25XJ; 5-Bromo-6-phenylisocytosine; CHEBI:31307; 2-Amino-5-Bromo-6-Phenylpyrimidin-4-Ol
• Cross-matching ID:
  PubChem CID: 135413497
  ChEBI ID: CHEMBL37387
  CAS Number: CAS 56741-95-8
  TTD Drug ID: D07RPR
  INTEDE Drug ID: DR1791

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.02	8.97e-3	76/85 (89.41%)	SERPINA1;VWF;C1QB;...
Mineral absorption	1.93	8.97e-3	48/60 (80%)	MT1X;MT1G;MT1H;...
Renin-angiotensin system	1.91	8.97e-3	20/23 (86.96%)	CPA3;AGTR1;CTSG;...
Pathways of neurodegeneration	-1.76	3.88e-2	354/475 (74.53%)	MAPK9;NDUFA4;NDUFB6;...
Mitophagy	-1.76	4.12e-2	56/68 (82.35%)	TP53;BECN1;SP1;...
Thermogenesis	-1.83	1.48e-2	173/232 (74.57%)	NDUFA4;PRDM16;NDUFB6;...
Phagosome	-1.86	1.33e-2	118/152 (77.63%)	THBS4;FCGR2B;ATP6V0E1;...
Protein processing in endoplasmic reticulum	-1.89	1.39e-2	127/171 (74.27%)	DDOST;SEC61A1;RRBP1;...
Parkinson disease	-1.97	3.70e-3	176/249 (70.68%)	MAPK9;NDUFA4;NDUFB6;...
Citrate cycle (TCA cycle)	-2.06	0.00e+0	30/30 (100%)	ACO2;MDH2;PDHB;...
Oxidative phosphorylation	-2.12	0.00e+0	93/133 (69.92%)	COX6B1;NDUFS4;ATP6V1E1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 3.33uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 3.33uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼