General Information of Drug (ID: DMMZ4E9)

Drug Name
Merbarone Drug Info
Synonyms NSC-336628
Cross-matching ID
PubChem CID
4990817
ChEBI ID
CHEMBL1765797
CAS Number
CAS 97534-21-9
TTD Drug ID
D00VZF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 1.87 6.21e-2 86/96 (89.58%) GNAS;PRKACB;TGFB1;...
Fructose and mannose metabolism 1.81 8.07e-2 30/33 (90.91%) AKR1B10;AKR1B1;PFKL;...
Vibrio cholerae infection 1.78 6.62e-2 44/50 (88%) GNAS;PRKACB;PLCG2;...
Galactose metabolism 1.73 1.02e-1 26/31 (83.87%) AKR1B10;AKR1B1;PFKL;...
Fatty acid elongation 1.72 8.45e-2 19/27 (70.37%) HACD1;HADHB;TECR;...
Glycerolipid metabolism 1.71 8.07e-2 44/61 (72.13%) AKR1B10;AKR1B1;LIPG;...
Pentose and glucuronate interconversions 1.70 7.81e-2 17/34 (50%) AKR1B10;AKR1B1;SORD;...
Hypertrophic cardiomyopathy 1.68 8.07e-2 81/90 (90%) TGFB1;TTN;ITGA6;...
Citrate cycle (TCA cycle) 1.67 8.28e-2 30/30 (100%) DLD;ACO1;SUCLG1;...
MicroRNAs in cancer 1.63 1.14e-1 146/310 (47.1%) CD44;FGFR3;GLS;...
Glutathione metabolism 1.61 1.32e-1 43/57 (75.44%) GPX2;GCLC;G6PD;...
DNA replication 1.58 1.61e-1 34/36 (94.44%) RFC5;MCM6;MCM5;...
Phospholipase D signaling pathway 1.56 1.69e-1 134/148 (90.54%) GNAS;F2R;PDGFRA;...
Central carbon metabolism in cancer 1.54 1.85e-1 67/70 (95.71%) FGFR3;GLS;PFKL;...
Carbohydrate digestion and absorption 1.52 2.21e-1 37/47 (78.72%) SLC37A4;AKT3;PIK3R1;...
Choline metabolism in cancer 1.51 2.25e-1 84/98 (85.71%) PDGFRA;PDGFC;AKT3;...
Acute myeloid leukemia 1.51 2.21e-1 66/67 (98.51%) RUNX1;LEF1;AKT3;...
Regulation of actin cytoskeleton 1.47 2.70e-1 185/218 (84.86%) FGFR3;F2R;GSN;...
Proximal tubule bicarbonate reclamation 1.44 3.20e-1 21/23 (91.3%) GLS;GLUD2;GLUD1;...
Asthma 1.44 3.25e-1 25/31 (80.65%) CD40;HLA-DQA1;CCL11;...
Adrenergic signaling in cardiomyocytes 1.43 3.25e-1 130/150 (86.67%) GNAS;PRKACB;ATP2A2;...
Pancreatic secretion 1.42 3.23e-1 87/102 (85.29%) GNAS;PRSS1;ATP2A2;...
Arginine and proline metabolism 1.42 3.26e-1 39/50 (78%) CKM;GOT1;ARG2;...
Lysosome 1.42 3.19e-1 115/128 (89.84%) SORT1;LAPTM4B;NPC2;...
Renin secretion 1.41 3.09e-1 61/69 (88.41%) GNAS;PTGER4;GUCY1A1;...
Collecting duct acid secretion 1.39 3.56e-1 22/27 (81.48%) ATP6V1D;CA2;ATP6V1G1;...
Gap junction 1.38 3.58e-1 72/88 (81.82%) GNAS;GUCY1A1;PRKACB;...
Pantothenate and CoA biosynthesis 1.38 3.60e-1 14/21 (66.67%) DPYD;AASDHPPT;ALDH1B1
Platelet activation 1.38 3.54e-1 106/124 (85.48%) GNAS;GUCY1A1;F2R;...
Mucin type O-glycan biosynthesis 1.36 3.58e-1 20/36 (55.56%) GALNT3;GALNT12;ST6GALNAC2;...
Non-alcoholic fatty liver disease -1.20 5.44e-1 126/155 (81.29%) ADIPOQ;ADIPOR1;NR1H3;...
NF-kappa B signaling pathway -1.21 5.44e-1 90/104 (86.54%) TNFSF11;SYK;TICAM1;...
Protein export -1.22 5.40e-1 17/23 (73.91%) SEC61G;SEC62;SRP9;...
Sulfur metabolism -1.23 5.24e-1 9/10 (90%) SELENBP1
Viral myocarditis -1.24 5.26e-1 53/60 (88.33%) ICAM1;HLA-F;SGCB;...
Aminoacyl-tRNA biosynthesis -1.24 5.44e-1 15/66 (22.73%) TARS2;GATC;HARS2;...
Bladder cancer -1.25 5.18e-1 40/41 (97.56%) MMP9;E2F3;EGFR;...
African trypanosomiasis -1.25 5.29e-1 32/37 (86.49%) HPR;ICAM1;VCAM1;...
Salmonella infection -1.26 5.29e-1 198/249 (79.52%) MAPK14;MYO6;ACTR3B;...
Spliceosome -1.30 4.30e-1 101/150 (67.33%) HNRNPM;SNRPC;BCAS2;...
Primary bile acid biosynthesis -1.32 4.07e-1 15/17 (88.24%) AKR1D1;SLC27A5;CYP7A1;...
Lipid and atherosclerosis -1.33 3.76e-1 190/215 (88.37%) MAP2K3;IKBKG;AGER;...
Epithelial cell signaling in Helicobacter pylori infect... -1.34 3.67e-1 62/70 (88.57%) ADAM17;IKBKG;ATP6V0C;...
Kaposi sarcoma-associated herpesvirus infection -1.35 3.75e-1 172/193 (89.12%) ATG14;SYK;TICAM1;...
Rheumatoid arthritis -1.35 3.92e-1 78/93 (83.87%) ATP6V0C;IL23A;ATP6V1B1;...
Breast cancer -1.36 3.76e-1 119/147 (80.95%) FZD10;RPS6KB2;FGF5;...
Phototransduction -1.38 3.63e-1 21/29 (72.41%) GRK1;PDE6A;RHO;...
TNF signaling pathway -1.38 3.89e-1 103/112 (91.96%) MMP9;MAPK14;CREB3L1;...
Viral protein interaction with cytokine and cytokine re... -1.40 3.55e-1 84/100 (84%) CCL4;IL10RB;CX3CL1;...
Cellular senescence -1.43 3.11e-1 139/156 (89.1%) E2F3;MAPK14;GADD45G;...
Malaria -1.44 3.23e-1 44/50 (88%) THBS4;VCAM1;IL6;...
alpha-Linolenic acid metabolism -1.49 2.51e-1 17/25 (68%) PLA2G4C;FADS2;PLA2G10;...
Terpenoid backbone biosynthesis -1.53 2.10e-1 18/22 (81.82%) PDSS2;ICMT;PCYOX1;...
IL-17 signaling pathway -1.53 2.20e-1 84/94 (89.36%) MMP9;MUC5B;MAPK14;...
Antigen processing and presentation -1.67 6.90e-2 60/78 (76.92%) TAP2;PSME2;RFXANK;...
Pertussis -1.71 5.85e-2 64/76 (84.21%) GNAI3;RELA;MAPK10;...
Thiamine metabolism -1.71 7.32e-2 12/15 (80%) ALPI;ALPP;TPK1;...
PPAR signaling pathway -1.72 8.57e-2 66/74 (89.19%) PDPK1;ACSBG1;SLC27A5;...
Mineral absorption -1.78 8.21e-2 48/60 (80%) ATP7B;ATP1A1;FTH1;...
Legionellosis -1.78 1.64e-1 51/57 (89.47%) HSF1;SAR1A;CASP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H