Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMZNSC)

Drug Name
AM-92016 Drug Info
Synonyms
COMPOUND II; N-(4-(3-((2-(3,4-Dichlorophenyl)ethyl)methylamino)-2-hydroxypropoxy)phenyl)methanesulfonamide; AM-92016; Bio2_000288; AC1L1CZF; Msaph-2ClPhEA-2-propanol; CBiol_001738; KBioGR_000288; BSPBio_001568; KBioSS_000288; CHEMBL43527; AC1Q3O93; SCHEMBL9655059; KBio3_000575; CHEBI:91532; KBio3_000576; KBio2_002856; KBio2_005424; KBio2_000288; Bio1_000513; HMS1791O10; Bio1_001002; Bio1_000024; HMS1989O10; Bio2_000768; AC-115; IDI1_034038; NCGC00024837-04; NCGC00024837-03; NCGC00024837-02; BRD-A11813248-003-01-6; BRD-A11813248-001-02-8
Cross-matching ID
PubChem CID
133104
CAS Number
CAS 178894-81-0
TTD Drug ID
D03KGJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.38 0.00e+0 19/20 (95%) SQLE;DHCR24;MSMO1;...
Metabolism of xenobiotics by cytochrome P450 2.26 0.00e+0 49/77 (63.64%) GSTP1;GSTM3;ADH1B;...
Steroid hormone biosynthesis 2.24 0.00e+0 43/61 (70.49%) AKR1C2;AKR1C1;HSD17B2;...
Ovarian steroidogenesis 2.12 0.00e+0 41/51 (80.39%) LDLR;SCARB1;HSD17B2;...
Terpenoid backbone biosynthesis 2.03 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;FDPS;...
Glutathione metabolism 1.78 1.67e-2 43/57 (75.44%) GSTP1;GSTM3;CHAC1;...
alpha-Linolenic acid metabolism 1.74 1.79e-2 17/25 (68%) FADS2;PLA2G4A;PLA2G10;...
Biosynthesis of unsaturated fatty acids 1.74 1.67e-2 21/27 (77.78%) SCD;FADS1;FADS2;...
Fat digestion and absorption 1.72 2.23e-2 35/43 (81.4%) ACAT2;CD36;SCARB1;...
Drug metabolism 1.69 2.76e-2 78/151 (51.66%) GSTP1;GSTM3;ADH1B;...
PPAR signaling pathway 1.68 3.26e-2 66/74 (89.19%) HMGCS1;SCD;CD36;...
Retinol metabolism 1.65 4.94e-2 41/68 (60.29%) ADH1B;ADH5;CYP3A5;...
African trypanosomiasis -1.67 4.67e-2 32/37 (86.49%) PLCB1;ICAM1;LAMA4;...
Small cell lung cancer -1.69 4.48e-2 90/92 (97.83%) RB1;LAMC1;ITGAV;...
Asthma -1.71 4.35e-2 25/31 (80.65%) IL10;CD40LG;CD40;...
Epstein-Barr virus infection -1.73 3.27e-2 189/202 (93.56%) CCNA2;MAPK8;PSMD12;...
Viral myocarditis -1.76 2.60e-2 53/60 (88.33%) ITGAL;CD86;HLA-G;...
IL-17 signaling pathway -1.82 1.31e-2 84/94 (89.36%) CCL7;HSP90B1;MAPK8;...
Natural killer cell mediated cytotoxicity -1.85 6.68e-3 99/131 (75.57%) IFNAR2;CD244;CD48;...
Antigen processing and presentation -1.85 7.79e-3 60/78 (76.92%) HSPA4;TAP2;CTSL;...
Viral protein interaction with cytokine and cytokine re... -1.92 0.00e+0 84/100 (84%) IL18R1;CCL7;IL10RB;...
Autoimmune thyroid disease -2.06 0.00e+0 46/53 (86.79%) CD86;HLA-G;HLA-DQB1;...
Graft-versus-host disease -2.30 0.00e+0 32/42 (76.19%) CD86;HLA-G;HLA-DQB1;...
Type I diabetes mellitus -2.34 0.00e+0 38/43 (88.37%) CD86;HLA-G;HLA-DQB1;...
Allograft rejection -2.35 0.00e+0 32/38 (84.21%) CD86;HLA-G;HLA-DQB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H