Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN0EMP)

Drug Name
EPICATECHIN Drug Info
Synonyms
(-)-Epicatechin; Epicatechin; 490-46-0; L-Epicatechin; (-)-Epicatechol; l-Acacatechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; Epicatechol; l-Epicatechol; (-)epicatechin; (2R,3R)-(-)-Epicatechin; UNII-34PHS7TU43; epi-Catechin; epi-Catechol; CCRIS 7097; EINECS 207-710-1; NSC 81161; Epicatechol, (-)-; CHEBI:90; 34PHS7TU43; PFTAWBLQPZVEMU-UKRRQHHQSA-N; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; AK105372; C15H14O6
Cross-matching ID
PubChem CID
72276
ChEBI ID
CHEMBL583912
CAS Number
CAS 17334-50-8
TTD Drug ID
D05TPI
VARIDT Drug ID
DR01463

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.02 0.00e+0 52/108 (48.15%) IMP3;MPHOSPH10;POP4;...
Proteasome 1.89 3.74e-2 44/46 (95.65%) PSMD3;PSMB3;PSMA4;...
Fanconi anemia pathway 1.87 2.80e-2 36/54 (66.67%) CENPX;FANCL;FANCI;...
DNA replication 1.84 3.27e-2 34/36 (94.44%) MCM6;POLE2;PCNA;...
Mineral absorption -1.83 1.77e-2 48/60 (80%) SLC39A4;CYBRD1;FTL;...
Proximal tubule bicarbonate reclamation -1.84 1.91e-2 21/23 (91.3%) GLUD2;ATP1B3;PCK1;...
Melanoma -1.84 2.38e-2 68/72 (94.44%) NRAS;PDGFD;FGF21;...
Phenylalanine metabolism -1.89 2.12e-2 14/17 (82.35%) DDC;AOC3;AOC2;...
Tyrosine metabolism -1.99 1.06e-2 30/36 (83.33%) DDC;AOC3;ADH6;...
Steroid biosynthesis -2.13 0.00e+0 19/20 (95%) SOAT1;DHCR7;SQLE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H