Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN2Q7Y)

Drug Name
FTI 276 Drug Info
Synonyms FTI-276; FTI276
Cross-matching ID
PubChem CID
395754
ChEBI ID
CHEMBL94119
CAS Number
CAS 170006-72-1
TTD Drug ID
D0M5PB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.29 0.00e+0 34/36 (94.44%) POLE2;FEN1;RFC3;...
Proteasome 2.02 0.00e+0 44/46 (95.65%) PSMD6;PSMA3;PSMA2;...
Mismatch repair 1.98 1.61e-3 22/23 (95.65%) MSH6;RFC3;EXO1;...
Homologous recombination 1.97 1.20e-3 35/41 (85.37%) RAD54B;TOPBP1;SSBP1;...
Spliceosome 1.94 9.64e-4 101/150 (67.33%) HSPA8;PRPF4;LSM6;...
Cell cycle 1.86 4.01e-3 110/124 (88.71%) CDC25A;CCNB2;CCNA2;...
Ribosome biogenesis in eukaryotes 1.86 3.44e-3 52/108 (48.15%) RPP38;POP5;POP4;...
Fanconi anemia pathway 1.82 4.82e-3 36/54 (66.67%) USP1;FANCI;RMI1;...
Aminoacyl-tRNA biosynthesis 1.69 2.30e-2 15/66 (22.73%) IARS2;QRSL1;DARS2;...
Progesterone-mediated oocyte maturation 1.69 2.12e-2 75/100 (75%) CDC25A;CCNB2;CCNA2;...
Oocyte meiosis 1.67 2.41e-2 90/129 (69.77%) CCNB2;CCNE2;CDC20;...
Base excision repair 1.65 2.77e-2 29/33 (87.88%) POLE2;FEN1;TDG;...
Pyrimidine metabolism 1.64 2.63e-2 40/56 (71.43%) RRM2;NME4;CTPS1;...
RNA transport 1.63 2.65e-2 128/186 (68.82%) KPNB1;EIF1AX;RPP38;...
Nucleotide excision repair 1.62 2.89e-2 40/47 (85.11%) POLE2;RFC3;RFC2;...
MicroRNAs in cancer -1.67 4.49e-2 146/310 (47.1%) PDGFA;RASSF1;EZR;...
AGE-RAGE signaling pathway in diabetic complications -1.68 4.48e-2 97/100 (97%) PLCB2;NRAS;CDKN1B;...
NF-kappa B signaling pathway -1.68 4.62e-2 90/104 (86.54%) TRADD;BTK;TNFSF14;...
Bladder cancer -1.69 4.37e-2 40/41 (97.56%) EGFR;NRAS;MMP1;...
Metabolism of xenobiotics by cytochrome P450 -1.70 4.44e-2 49/77 (63.64%) CYP2F1;ADH5;AKR7A2;...
Fluid shear stress and atherosclerosis -1.72 4.24e-2 123/139 (88.49%) ACVR1;RELA;MAPK14;...
PPAR signaling pathway -1.73 4.21e-2 66/74 (89.19%) UCP1;SLC27A2;FABP7;...
Cysteine and methionine metabolism -1.74 3.86e-2 43/50 (86%) TST;MPST;CDO1;...
Glycosaminoglycan degradation -1.77 3.24e-2 19/19 (100%) HPSE2;HYAL4;HPSE;...
Mitophagy -1.78 3.25e-2 56/68 (82.35%) CSNK2A1;PINK1;RELA;...
Sulfur metabolism -1.78 3.52e-2 9/10 (90%) PAPSS1;TST;MPST;...
Glycerolipid metabolism -1.78 3.84e-2 44/61 (72.13%) AKR1B1;ALDH3A2;LPIN2;...
Cholesterol metabolism -1.83 2.19e-2 44/50 (88%) LIPA;APOE;APOC1;...
Galactose metabolism -1.87 1.91e-2 26/31 (83.87%) UGP2;AKR1B1;HK1;...
Glycine, serine and threonine metabolism -1.88 1.76e-2 31/40 (77.5%) PSPH;AMT;ALDH7A1;...
Lysosome -1.92 1.79e-2 115/128 (89.84%) CTSE;LIPA;HEXA;...
Pertussis -1.96 7.83e-3 64/76 (84.21%) RELA;ITGB1;MAPK14;...
Ferroptosis -1.97 6.27e-3 36/41 (87.8%) ACSL4;GPX4;SLC39A8;...
Complement and coagulation cascades -1.99 7.83e-3 76/85 (89.41%) C1QA;PROS1;F8;...
Rheumatoid arthritis -2.02 5.22e-3 78/93 (83.87%) ITGB2;HLA-DOA;FLT1;...
Staphylococcus aureus infection -2.07 7.83e-3 72/95 (75.79%) ITGB2;HLA-DOA;KRT24;...
Mineral absorption -2.08 1.57e-2 48/60 (80%) ATP2B4;ATP7A;FTL;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H