Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN4ABU)

Drug Name
[125I]iodophenpropit Drug Info
Synonyms
(1S)-1-[3-(3H-Imidazol-4-yl)propylsulfanyl]-N-[2-(4-iodophenyl)ethyl]methanediamine; (1S)-1-[3-(3H-imidazol-4-yl)propylsulfanyl]-N-[2-(4-iodophenyl)ethyl]methanediamine; [125I]IODOPHENPROPIT; AC1NSK68; GTPL3960; GTPL1266; IODOPHENPROPIT
Cross-matching ID
PubChem CID
5311186
TTD Drug ID
D03ECU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.59 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Arginine biosynthesis 1.94 1.80e-2 17/22 (77.27%) GLUL;ASS1;ARG2;...
Biosynthesis of unsaturated fatty acids 1.94 1.20e-2 21/27 (77.78%) SCD;FADS1;FADS2;...
Synthesis and degradation of ketone bodies 1.93 1.50e-2 9/10 (90%) HMGCS1;ACAT2
Ovarian steroidogenesis 1.90 1.68e-2 41/51 (80.39%) CYP1B1;LDLR;GNAS;...
Steroid hormone biosynthesis 1.89 1.40e-2 43/61 (70.49%) CYP1B1;AKR1C3;HSD17B7;...
Terpenoid backbone biosynthesis 1.88 1.37e-2 18/22 (81.82%) HMGCS1;FDPS;ACAT2;...
MicroRNAs in cancer 1.85 1.50e-2 146/310 (47.1%) CYP1B1;CDKN1B;CCND2;...
Focal adhesion 1.84 1.47e-2 180/201 (89.55%) COMP;CCND2;LAMB1;...
Complement and coagulation cascades 1.83 1.44e-2 76/85 (89.41%) CFD;CD46;TFPI;...
Taurine and hypotaurine metabolism 1.83 1.42e-2 8/11 (72.73%) GAD1;GGT1;GAD2;...
Salivary secretion 1.80 1.90e-2 76/93 (81.72%) CST1;GNAS;CST3;...
Gap junction 1.79 2.13e-2 72/88 (81.82%) GJA1;GNAS;PDGFA;...
Mitophagy 1.76 2.32e-2 56/68 (82.35%) BNIP3L;CITED2;GABARAPL1;...
Fluid shear stress and atherosclerosis 1.74 2.49e-2 123/139 (88.49%) GSTM3;SQSTM1;MAP3K5;...
PPAR signaling pathway 1.73 2.71e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Cortisol synthesis and secretion 1.73 2.62e-2 58/65 (89.23%) LDLR;NR0B1;GNAS;...
Mucin type O-glycan biosynthesis 1.71 2.81e-2 20/36 (55.56%) GALNT3;GALNT11;GALNT6;...
Endocrine and other factor-regulated calcium reabsorpti... 1.69 3.16e-2 49/53 (92.45%) GNAS;ADCY9;PRKCA;...
Pancreatic secretion 1.67 3.91e-2 87/102 (85.29%) GNAS;CLCA2;PLA2G2A;...
Aldosterone synthesis and secretion 1.67 3.72e-2 85/98 (86.73%) LDLR;GNAS;PDE2A;...
Glutathione metabolism 1.64 4.86e-2 43/57 (75.44%) GSTM3;IDH1;G6PD;...
Lysosome 1.64 4.71e-2 115/128 (89.84%) CTSK;TPP1;CTSA;...
Cytosolic DNA-sensing pathway -1.65 3.59e-2 52/63 (82.54%) POLR2L;RIPK1;CASP1;...
Prion disease -1.66 3.57e-2 209/273 (76.56%) C1QA;RYR1;NDUFB2;...
Mismatch repair -1.66 3.87e-2 22/23 (95.65%) MSH2;POLD1;POLD4;...
Base excision repair -1.69 2.84e-2 29/33 (87.88%) APEX2;POLB;MUTYH;...
Protein export -1.71 2.74e-2 17/23 (73.91%) SEC61B;HSPA5;SEC11A;...
Homologous recombination -1.72 3.04e-2 35/41 (85.37%) BABAM1;BABAM2;RAD52;...
Parkinson disease -1.73 2.95e-2 176/249 (70.68%) NDUFB2;CAMK2G;PSMC2;...
RNA polymerase -1.73 3.37e-2 23/31 (74.19%) POLR2J;POLR2D;POLR2L;...
Ribosome -1.90 3.81e-3 113/158 (71.52%) RPL37A;RPS3;RPS27;...
Proteasome -1.93 1.52e-3 44/46 (95.65%) IFNG;PSMA1;ADRM1;...
RNA transport -1.95 0.00e+0 128/186 (68.82%) TGS1;SNUPN;ELAC2;...
Spliceosome -2.12 0.00e+0 101/150 (67.33%) PRPF6;HNRNPM;SNRPD2;...
DNA replication -2.12 0.00e+0 34/36 (94.44%) MCM4;POLD1;POLD4;...
Ribosome biogenesis in eukaryotes -2.56 0.00e+0 52/108 (48.15%) MDN1;EIF6;RPP30;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H