Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN6CAG)

Drug Name
Tiapride Drug Info
Synonyms
tiapride; 51012-32-9; Thiapride; Tiapridal; N-(2-(Diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamide; Tiapridum [INN-Latin]; Tiaprida [INN-Spanish]; UNII-LAH70H9JPH; FLO 1347; Tiapride [INN:BAN:DCF]; Tiapride HCl; EINECS 256-907-9; LAH70H9JPH; BRN 2390588; JTVPZMFULRWINT-UHFFFAOYSA-N; BENZAMIDE, N-(2-(DIETHYLAMINO)ETHYL)-2-METHOXY-5-(METHYLSULFONYL)-; N-(2-(Diethylamino)ethyl)-5-(methylsulfonyl)-o-anisamide; Tiapridum; Tiaprida; Benzamide, N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-; NCGC00015996-02; SPI-860
Cross-matching ID
PubChem CID
5467
ChEBI ID
CHEMBL84158
CAS Number
CAS 51012-32-9
TTD Drug ID
D02LCR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.16 0.00e+0 34/36 (94.44%) PCNA;MCM5;MCM2;...
Base excision repair 1.90 5.03e-3 29/33 (87.88%) PCNA;FEN1;HMGB1;...
Starch and sucrose metabolism 1.90 3.35e-3 25/36 (69.44%) GPI;HK2;MGAM;...
Systemic lupus erythematosus 1.89 2.51e-3 45/135 (33.33%) CD40;HLA-DQA1;SNRPB;...
Pentose phosphate pathway 1.78 3.42e-2 25/30 (83.33%) GPI;PGD;ALDOA;...
Mismatch repair 1.77 2.85e-2 22/23 (95.65%) PCNA;MSH6;MLH1;...
Intestinal immune network for IgA production 1.77 2.59e-2 38/48 (79.17%) CD40;HLA-DQA1;TGFB1;...
Asthma 1.75 2.89e-2 25/31 (80.65%) CD40;HLA-DQA1;PRG2;...
Neomycin, kanamycin and gentamicin biosynthesis 1.72 3.80e-2 5/5 (100%) HK2;HK3;HK1
Spliceosome 1.70 4.63e-2 101/150 (67.33%) HSPA6;HNRNPU;SF3B3;...
Fructose and mannose metabolism 1.70 4.94e-2 30/33 (90.91%) HK2;ALDOA;KHK;...
Glycolysis / Gluconeogenesis 1.69 4.86e-2 56/67 (83.58%) GPI;PGAM1;HK2;...
Glycine, serine and threonine metabolism 1.69 4.49e-2 31/40 (77.5%) PGAM1;GNMT;CBS;...
Steroid biosynthesis 1.67 4.96e-2 19/20 (95%) DHCR24;DHCR7;SQLE;...
Maturity onset diabetes of the young 1.66 4.84e-2 21/26 (80.77%) HHEX;HES1;PAX6;...
Viral protein interaction with cytokine and cytokine re... -1.76 3.98e-2 84/100 (84%) PF4;CX3CL1;CCL20;...
Oxidative phosphorylation -1.77 3.98e-2 93/133 (69.92%) NDUFB3;ATP12A;ATP5ME;...
Epithelial cell signaling in Helicobacter pylori infect... -1.84 2.74e-2 62/70 (88.57%) ATP6V1F;ADAM17;JUN;...
Nicotine addiction -1.90 1.99e-2 32/40 (80%) GABRG2;GABRB1;GRIA3;...
TNF signaling pathway -2.06 4.97e-3 103/112 (91.96%) IL6;TAB2;ATF2;...
IL-17 signaling pathway -2.09 9.95e-3 84/94 (89.36%) TRAF6;MMP1;CHUK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H