Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN6EZY)

Drug Name
Vitamin K Drug Info
Synonyms 12001-79-5; MBWXNTAXLNYFJB-LKUDQCMESA-N; 81818-54-4
Cross-matching ID
PubChem CID
5280483
ChEBI ID
CHEMBL94399
CAS Number
CAS 12001-79-5
TTD Drug ID
D07QPA
INTEDE Drug ID
DR1702

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.00 1.08e-2 113/158 (71.52%) RPS4Y1;RPL10;RPL8;...
Circadian rhythm 1.99 5.41e-3 26/31 (83.87%) BHLHE41;CREB1;PRKAB1;...
Cytokine-cytokine receptor interaction -1.64 4.64e-2 246/295 (83.39%) CCL21;CXCL2;CSF1R;...
Viral protein interaction with cytokine and cytokine re... -1.67 3.75e-2 84/100 (84%) CCL21;CXCL2;CSF1R;...
B cell receptor signaling pathway -1.68 3.60e-2 71/81 (87.65%) NFKBIA;LILRA1;PPP3CC;...
Ascorbate and aldarate metabolism -1.69 3.12e-2 15/30 (50%) UGT2B17;UGT2B28;ALDH3A2;...
Metabolism of xenobiotics by cytochrome P450 -1.72 2.54e-2 49/77 (63.64%) UGT2B17;GSTO1;GSTT1;...
Pertussis -1.73 2.40e-2 64/76 (84.21%) IL10;CALML4;PYCARD;...
Linoleic acid metabolism -1.73 2.50e-2 21/29 (72.41%) PLA2G5;CYP2C8;CYP1A2;...
Phagosome -1.75 1.87e-2 118/152 (77.63%) TAP2;ITGB1;HLA-DPB1;...
Malaria -1.75 2.02e-2 44/50 (88%) TNF;THBS1;VCAM1;...
Arachidonic acid metabolism -1.77 1.64e-2 48/61 (78.69%) CYP2B6;LTA4H;CYP2C8;...
Vitamin digestion and absorption -1.79 1.70e-2 17/24 (70.83%) APOA4;TCN2;APOA1;...
Synthesis and degradation of ketone bodies -1.82 8.44e-3 9/10 (90%) HMGCS2;HMGCS1
Fat digestion and absorption -1.83 9.37e-3 35/43 (81.4%) PLA2G5;MOGAT2;AGPAT2;...
Steroid hormone biosynthesis -1.85 9.37e-3 43/61 (70.49%) HSD17B1;CYP1A2;CYP11A1;...
Ovarian steroidogenesis -1.87 6.70e-3 41/51 (80.39%) SCARB1;HSD17B1;LHB;...
Ether lipid metabolism -1.87 7.81e-3 32/49 (65.31%) PLA2G4A;PLPP3;PLAAT3;...
Retinol metabolism -1.90 7.50e-3 41/68 (60.29%) CYP2B6;ADH1B;CYP2C8;...
Ferroptosis -1.91 9.37e-3 36/41 (87.8%) SLC39A14;SLC3A2;GCLM;...
Arginine biosynthesis -1.98 6.25e-3 17/22 (77.27%) OTC;NOS3;GLUD2;...
Complement and coagulation cascades -2.29 0.00e+0 76/85 (89.41%) CR2;F13A1;F2;...
Staphylococcus aureus infection -2.52 0.00e+0 72/95 (75.79%) KRT31;C3AR1;FPR2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H