Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN7EUO)

Drug Name
N6022 Drug Info
Synonyms
N6022; 1208315-24-5; N-6022; UNII-80LIU5P95D; 80LIU5P95D; CHEMBL1738699; 3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid; 3-{1-(4-Carbamoyl-2-Methylphenyl)-5-[4-(1h-Imidazol-1-Yl)phenyl]-1h-Pyrrol-2-Yl}propanoic Acid; N 6022; YVPGZQLRPAGKLA-UHFFFAOYSA-N; 3-[1-(4-carbamoyl-2-methylphenyl)-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrol-2-yl]propanoic acid; SCHEMBL244480; EX-A343; MolPort-035-789-691; HMS3653J15; BCP09367; s7589; ZINC66156654; BDBM50354475; 2573AH; AKOS030526322; DB12206
Cross-matching ID
PubChem CID
44623946
ChEBI ID
CHEMBL1738699
CAS Number
CAS 1208315-24-5
TTD Drug ID
D09LPV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.91 1.91e-2 34/36 (94.44%) PCNA;MCM3;MCM7;...
Base excision repair 1.82 3.18e-2 29/33 (87.88%) PCNA;HMGB1;PARP4;...
Type I diabetes mellitus -1.74 3.31e-2 38/43 (88.37%) CD86;HLA-DOA;INS;...
Folate biosynthesis -1.74 3.67e-2 23/26 (88.46%) MOCS2;SPR;ALPL;...
Oxidative phosphorylation -1.82 1.32e-2 93/133 (69.92%) NDUFA3;NDUFS7;SDHB;...
Intestinal immune network for IgA production -1.84 1.13e-2 38/48 (79.17%) IL15RA;ICOSLG;CCR10;...
Proximal tubule bicarbonate reclamation -1.84 1.10e-2 21/23 (91.3%) CA4;ATP1A2;FXYD2;...
Drug metabolism -1.92 0.00e+0 78/151 (51.66%) CMPK1;CYP2C9;ALDH3B1;...
Tyrosine metabolism -1.93 0.00e+0 30/36 (83.33%) ALDH3B1;ADH1A;ADH6;...
Retinol metabolism -1.98 0.00e+0 41/68 (60.29%) CYP2C9;ADH1A;DHRS3;...
Metabolism of xenobiotics by cytochrome P450 -2.28 0.00e+0 49/77 (63.64%) CYP2C9;ALDH3B1;ADH1A;...
Mineral absorption -2.56 0.00e+0 48/60 (80%) SLC39A4;SLC30A1;ATP2B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H