Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN7J43)

• Drug Name: Benzo(a)pyrene Drug Info
• Synonyms: benzo[a]pyrene; 3,4-Benzopyrene; benzo[pqr]tetraphene; BENZO(A)PYRENE; 3,4-Benzpyrene; Benzpyrene; benzo[def]chrysene; 6,7-Benzopyrene; Benz[a]pyrene; 3,4-BP; 3,4-Benz[a]pyrene; 3,4-Benzopirene; 3,4-Benzpyren; Benzo[d,e,f]chrysene; Benz(a)pyrene; (B(a)P); B(a)P; BP; 3,4 Benzpyrene; RCRA waste number U022; Benzo(d,e,f)chrysene; 3,4-Benz(a)pyrene; NSC 21914; 3,4-Benzo(a)pyrene; B[a]p; 3,4-Benzpyren [German]; CCRIS 76; Benzo[A]-Pyrene; Benzo(def)chrysene; 3,4-benzylpyrene; 3,4-Benzopirene [Italian]
• Cross-matching ID:
  PubChem CID: 2336
  ChEBI ID: CHEMBL31184
  CAS Number: CAS 50-32-8
  VARIDT Drug ID: DR01618

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
p53 signaling pathway	2.13	0.00e+0	63/73 (86.3%)	TP53I3;CCND2;FAS;...
Histidine metabolism	2.00	5.47e-3	16/22 (72.73%)	ALDH3A1;AOC1;ALDH3A2;...
Notch signaling pathway	1.86	1.82e-2	49/59 (83.05%)	DVL3;RFNG;KAT2A;...
Mannose type O-glycan biosynthesis	1.75	4.74e-2	14/23 (60.87%)	RXYLT1;FUT9;POMGNT1;...
Spliceosome	-1.70	4.40e-2	101/150 (67.33%)	SRSF3;LSM4;SRSF10;...
Antigen processing and presentation	-1.74	3.00e-2	60/78 (76.92%)	NFYA;HSP90AA1;HSPA5;...
Phagosome	-1.80	1.58e-2	118/152 (77.63%)	FCGR2C;ATP6V0E2;RAB5C;...
Protein processing in endoplasmic reticulum	-1.83	1.23e-2	127/171 (74.27%)	CUL1;HYOU1;HSP90AB1;...
Pertussis	-1.84	1.47e-2	64/76 (84.21%)	GNAI3;IRAK4;MAPK1;...
Systemic lupus erythematosus	-1.97	4.61e-3	45/135 (33.33%)	C8G;C6;C9;...
Staphylococcus aureus infection	-2.05	0.00e+0	72/95 (75.79%)	DEFB1;MBL2;C3;...
Platelet activation	-2.08	0.00e+0	106/124 (85.48%)	ITPR1;F2;PLCB1;...
Complement and coagulation cascades	-2.25	0.00e+0	76/85 (89.41%)	MBL2;C3;SERPINA5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.08uM - 20uM	3H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.08uM - 20uM	24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼