Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN7Y9K)

Drug Name
Alpidem Drug Info
Synonyms
ALPIDEM; 82626-01-5; Ananxyl; Alpidemum [Latin]; UNII-I93SC245QZ; SL 80.0342-00; 2-(6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide; 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide; CHEMBL54349; I93SC245QZ; S-800342; NCGC00182850-01; 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-a)pyridin-3-acetamid; DSSTox_RID_83237; DSSTox_CID_28972; DSSTox_GSID_49046; Alpidemum; 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
Cross-matching ID
PubChem CID
54897
ChEBI ID
CHEMBL135649
CAS Number
CAS 82626-01-5
TTD Drug ID
D01XOD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Platelet activation 2.13 0.00e+0 106/124 (85.48%) ADCY1;MAPK1;PLCB3;...
Gap junction 2.11 0.00e+0 72/88 (81.82%) ADCY1;MAPK1;LPAR1;...
GnRH signaling pathway 1.83 4.39e-2 80/93 (86.02%) ADCY1;MAPK1;GNA11;...
Amoebiasis 1.83 3.51e-2 99/102 (97.06%) ADCY1;GNA11;PLCB3;...
Parathyroid hormone synthesis, secretion and action 1.79 4.18e-2 98/106 (92.45%) ADCY1;MAPK1;GNA11;...
p53 signaling pathway -1.67 4.12e-2 63/73 (86.3%) TP53I3;CDKN1A;BBC3;...
Synthesis and degradation of ketone bodies -1.68 4.34e-2 9/10 (90%) BDH1;BDH2;HMGCS1;...
Intestinal immune network for IgA production -1.69 4.07e-2 38/48 (79.17%) TNFRSF13B;IL15;TNFRSF17;...
Non-alcoholic fatty liver disease -1.78 2.17e-2 126/155 (81.29%) NDUFA9;ITCH;COX6A1;...
Thermogenesis -1.82 1.45e-2 173/232 (74.57%) RPS6KB2;ACTL6A;COX10;...
Terpenoid backbone biosynthesis -1.82 1.74e-2 18/22 (81.82%) DHDDS;HMGCR;HMGCS1;...
Steroid biosynthesis -1.84 1.81e-2 19/20 (95%) MSMO1;EBP;CYP51A1;...
Ribosome -2.00 4.82e-3 113/158 (71.52%) RPL35;RPS25;MRPL33;...
Mineral absorption -2.10 0.00e+0 48/60 (80%) SLC31A1;SLC11A2;ATP2B2;...
Oxidative phosphorylation -2.37 0.00e+0 93/133 (69.92%) NDUFA9;ATP6V1G1;COX6A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H