Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN84RM)

Drug Name
6-Formylindolo[3,2-b]carbazole Drug Info
Synonyms Indolo[3,2-b]carbazole-6-carbaldehyde; 1555757-10-2; indolo[3,2-b]carbazole-12-carbaldehyde; SCHEMBL528518; ANW-57186; MFCD23140892; ZINC39957465; AKOS015837457; AKOS025396684; FT-0678209
Cross-matching ID
PubChem CID
22245026
TTD Drug ID
DFBJ28

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Sulfur relay system -1.61 4.72e-2 5/8 (62.5%) MPST;TST
Ribosome -1.62 4.94e-2 113/158 (71.52%) RPL28;RPL37A;MRPS15;...
Mineral absorption -1.64 3.94e-2 48/60 (80%) ATP1B4;HEPH;FTL;...
Other glycan degradation -1.65 3.92e-2 13/18 (72.22%) GLB1;NEU2;MANBA;...
Glyoxylate and dicarboxylate metabolism -1.66 3.75e-2 23/30 (76.67%) MDH2;MMUT;AGXT;...
Fatty acid degradation -1.66 3.92e-2 40/43 (93.02%) ACSL4;HADHB;ACAA2;...
Cardiac muscle contraction -1.67 3.79e-2 64/87 (73.56%) MYH6;CACNB1;ATP2A1;...
Neutrophil extracellular trap formation -1.69 3.29e-2 101/189 (53.44%) SLC25A6;CYBB;CAMP;...
Butanoate metabolism -1.76 1.36e-2 23/28 (82.14%) ACSM5;EHHADH;ECHS1;...
Cholesterol metabolism -1.76 1.40e-2 44/50 (88%) LPL;LIPA;STARD3;...
Steroid hormone biosynthesis -1.77 1.44e-2 43/61 (70.49%) UGT2B28;HSD17B12;CYP7A1;...
Pentose phosphate pathway -1.78 1.26e-2 25/30 (83.33%) FBP2;RPE;DERA;...
Propanoate metabolism -1.82 9.52e-3 30/34 (88.24%) EHHADH;ECHS1;ACAT1;...
Lysosome -1.83 1.06e-2 115/128 (89.84%) HEXB;GAA;MAN2B1;...
Biosynthesis of unsaturated fatty acids -1.86 6.49e-3 21/27 (77.78%) FADS2;ELOVL6;HSD17B12;...
Ferroptosis -1.87 6.18e-3 36/41 (87.8%) ACSL4;STEAP3;FTL;...
PPAR signaling pathway -1.90 1.44e-3 66/74 (89.19%) SLC27A6;FABP1;DBI;...
Terpenoid backbone biosynthesis -1.99 1.73e-3 18/22 (81.82%) MVD;ACAT1;HMGCS1;...
Complement and coagulation cascades -2.00 2.16e-3 76/85 (89.41%) SERPINA5;C1QB;PROC;...
Nicotinate and nicotinamide metabolism -2.00 2.88e-3 25/35 (71.43%) NT5M;NT5E;NNMT;...
Protein processing in endoplasmic reticulum -2.11 4.33e-3 127/171 (74.27%) MBTPS2;CAPN2;BAG1;...
Steroid biosynthesis -2.34 0.00e+0 19/20 (95%) TM7SF2;SOAT1;SC5D;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 1.11uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H