General Information of Drug (ID: DMN8DQH)

Drug Name
Darusentan Drug Info
Synonyms Endothelin antagonist, BASF; HMR-4005; LU-127043; LU-135252
Cross-matching ID
PubChem CID
177236
ChEBI ID
CHEMBL23261
CAS Number
CAS 171714-84-4
TTD Drug ID
D0R7YY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway 1.79 9.94e-2 90/104 (86.54%) CCL4;CXCL12;RELB;...
Mismatch repair 1.57 5.92e-1 22/23 (95.65%) PCNA;LIG1;MLH1;...
DNA replication 1.55 5.08e-1 34/36 (94.44%) PCNA;LIG1;RFC4;...
Pentose phosphate pathway 1.51 5.16e-1 25/30 (83.33%) FBP1;PFKP;PGD;...
Arginine biosynthesis 1.49 4.81e-1 17/22 (77.27%) ARG1;ASS1;GLUL
Pyrimidine metabolism 1.48 4.49e-1 40/56 (71.43%) TYMS;CDA;NT5E;...
Protein export 1.40 7.33e-1 17/23 (73.91%) SEC61B;SRP72;SRP14;...
Nicotinate and nicotinamide metabolism 1.40 6.59e-1 25/35 (71.43%) CD38;NT5E;SIRT3;...
Nucleotide excision repair 1.40 5.87e-1 40/47 (85.11%) PCNA;RAD23B;LIG1;...
Steroid hormone biosynthesis 1.39 5.73e-1 43/61 (70.49%) CYP3A4;CYP2E1;CYP3A5;...
African trypanosomiasis 1.37 5.85e-1 32/37 (86.49%) HBB;IDO1;PLCB3;...
Mucin type O-glycan biosynthesis 1.37 5.41e-1 20/36 (55.56%) GALNT12;GALNT10;ST6GALNAC4;...
Mitophagy 1.34 6.10e-1 56/68 (82.35%) BNIP3L;TP53;RRAS2;...
Epithelial cell signaling in Helicobacter pylori infect... 1.33 6.27e-1 62/70 (88.57%) CCL5;CDC42;JUN;...
Ferroptosis 1.32 6.11e-1 36/41 (87.8%) FTH1;TP53;ACSL5;...
Pathways in cancer 1.10 7.43e-1 474/531 (89.27%) ESR1;VEGFA;EGLN3;...
Other types of O-glycan biosynthesis 1.10 7.36e-1 29/47 (61.7%) GALNT12;GALNT10;ST6GAL1;...
RNA transport 1.10 7.33e-1 128/186 (68.82%) EEF1A2;CASC3;EIF3H;...
Cholesterol metabolism 1.10 7.21e-1 44/50 (88%) LDLR;STAR;APOA2;...
Allograft rejection 1.09 7.21e-1 32/38 (84.21%) CD40;HLA-DOB;HLA-B;...
Cytokine-cytokine receptor interaction 1.09 7.11e-1 246/295 (83.39%) CCL4;CXCL12;CCL5;...
Renal cell carcinoma 1.09 7.02e-1 68/69 (98.55%) VEGFA;EGLN3;CDC42;...
AGE-RAGE signaling pathway in diabetic complications 1.09 6.94e-1 97/100 (97%) VEGFA;CDC42;COL3A1;...
RNA polymerase 1.09 6.89e-1 23/31 (74.19%) POLR1D;POLR2G;POLR2L;...
Parkinson disease 1.08 6.92e-1 176/249 (70.68%) GNAI1;SNCA;KIF5C;...
Chemokine signaling pathway 1.08 6.89e-1 163/192 (84.9%) CCL4;GNAI1;CXCL12;...
Primary immunodeficiency 1.07 7.06e-1 33/38 (86.84%) CD40;CD8A;DCLRE1C;...
MicroRNAs in cancer 1.07 7.10e-1 146/310 (47.1%) VEGFA;MARCKS;TP53;...
Serotonergic synapse 1.06 7.29e-1 97/114 (85.09%) ALOX5;GNAI1;PLCB3;...
Cellular senescence 1.06 7.17e-1 139/156 (89.1%) TP53;RRAS2;NFATC3;...
Osteoclast differentiation -1.23 5.23e-1 117/127 (92.13%) LCP2;NOX1;IFNGR1;...
Neutrophil extracellular trap formation -1.24 5.22e-1 101/189 (53.44%) CLEC7A;NCF4;FPR2;...
Endometrial cancer -1.24 5.13e-1 56/58 (96.55%) AKT3;GSK3B;PIK3CA;...
Aminoacyl-tRNA biosynthesis -1.24 5.09e-1 15/66 (22.73%) SARS2;IARS2;GATB;...
Pyruvate metabolism -1.25 5.05e-1 41/47 (87.23%) GRHPR;ACAT1;ACYP2;...
Synthesis and degradation of ketone bodies -1.25 5.16e-1 9/10 (90%) ACAT1;HMGCS1;ACAT2;...
Colorectal cancer -1.25 5.23e-1 84/86 (97.67%) AKT3;GSK3B;PMAIP1;...
Breast cancer -1.25 5.24e-1 119/147 (80.95%) AKT3;GSK3B;PIK3CA;...
Arginine and proline metabolism -1.26 5.28e-1 39/50 (78%) LAP3;SMS;GAMT;...
Cell adhesion molecules -1.26 5.25e-1 118/148 (79.73%) SELPLG;ICAM2;PTPRF;...
Hepatitis C -1.27 5.25e-1 139/157 (88.54%) IKBKE;CLDN8;IRF3;...
Chronic myeloid leukemia -1.27 5.29e-1 72/76 (94.74%) RUNX1;AKT3;PIK3CA;...
Staphylococcus aureus infection -1.35 5.13e-1 72/95 (75.79%) C1QB;KRT14;HLA-DRA;...
Kaposi sarcoma-associated herpesvirus infection -1.35 5.27e-1 172/193 (89.12%) MAPKAPK2;PPP3CA;IKBKE;...
Pancreatic secretion -1.36 5.26e-1 87/102 (85.29%) CTRB2;CELA2A;PNLIPRP2;...
Regulation of lipolysis in adipocytes -1.37 4.95e-1 52/55 (94.55%) NPR1;ADCY2;ADCY9;...
Legionellosis -1.38 4.85e-1 51/57 (89.47%) HSPA1A;RAB1A;TLR5;...
alpha-Linolenic acid metabolism -1.38 5.09e-1 17/25 (68%) ACOX1;PLA2G4A;PLA2G10;...
Systemic lupus erythematosus -1.38 5.27e-1 45/135 (33.33%) FCGR2A;HLA-DRB1;HLA-DPB1;...
Glycerolipid metabolism -1.44 5.28e-1 44/61 (72.13%) PLPP1;DGKQ;PNLIPRP2;...
Salivary secretion -1.47 4.51e-1 76/93 (81.72%) ATP2B2;CST5;GNAQ;...
Pathogenic Escherichia coli infection -1.48 4.89e-1 152/197 (77.16%) NFKBIB;ACTR2;NCKAP1;...
Propanoate metabolism -1.50 4.66e-1 30/34 (88.24%) ECHDC1;PCCA;ACAT1;...
Vasopressin-regulated water reabsorption -1.50 5.12e-1 40/44 (90.91%) ADCY9;DYNC1LI1;STX4;...
Mineral absorption -1.56 3.92e-1 48/60 (80%) ATP2B3;CYBRD1;SLC26A3;...
Ether lipid metabolism -1.56 4.68e-1 32/49 (65.31%) PLPP1;PLA2G7;PLA2G4A;...
Fatty acid elongation -1.59 4.54e-1 19/27 (70.37%) MECR;ECHS1;ELOVL4;...
Valine, leucine and isoleucine degradation -1.66 2.79e-1 42/48 (87.5%) BCAT2;PCCA;AACS;...
Glycerophospholipid metabolism -1.72 2.33e-1 71/98 (72.45%) PLPP1;DGKQ;LPIN1;...
Aldosterone-regulated sodium reabsorption -1.81 1.40e-1 34/37 (91.89%) ATP1B2;ATP1B1;HSD11B2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H