Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN8M5P)

Drug Name
PD-168393 Drug Info
Synonyms
PD168393; 194423-15-9; pd 168393; PD-168393; UNII-3R996Y9T0I; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide; N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide; CHEMBL285063; 3R996Y9T0I; C17H13BrN4O; N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-acrylamide; 2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-; 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-; nchembio866-comp2; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide
Cross-matching ID
PubChem CID
4708
ChEBI ID
CHEMBL285063
CAS Number
CAS 194423-15-9
TTD Drug ID
D01VFR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis 2.11 8.86e-3 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
ABC transporters 2.08 4.43e-3 37/45 (82.22%) ABCA5;TAP1;ABCA1;...
Metabolism of xenobiotics by cytochrome P450 2.07 2.95e-3 49/77 (63.64%) AKR1C1;GSTM3;CYP1B1;...
Complement and coagulation cascades 2.04 2.22e-3 76/85 (89.41%) FGG;FGB;CFB;...
Other glycan degradation 1.98 3.55e-3 13/18 (72.22%) NEU1;GLB1;MAN2B2;...
Glutathione metabolism 1.89 5.91e-3 43/57 (75.44%) GSTM3;GSTA1;IDH1;...
Sulfur metabolism 1.86 1.14e-2 9/10 (90%) SELENBP1;TST;SUOX;...
Staphylococcus aureus infection 1.80 2.33e-2 72/95 (75.79%) FGG;CFB;C1S;...
Peroxisome 1.80 2.26e-2 72/82 (87.8%) SOD2;CAT;IDH1;...
Herpes simplex virus 1 infection 1.80 2.04e-2 165/498 (33.13%) C3;STAT1;TAPBP;...
Coronavirus disease 1.77 2.18e-2 215/232 (92.67%) FGG;FGB;CFB;...
Ferroptosis 1.76 2.29e-2 36/41 (87.8%) HMOX1;CP;FTH1;...
Lysosome 1.74 2.39e-2 115/128 (89.84%) CTSA;NEU1;CTSK;...
Ovarian steroidogenesis 1.74 2.41e-2 41/51 (80.39%) AKR1C3;CYP1B1;GNAS;...
Tryptophan metabolism 1.72 2.60e-2 35/42 (83.33%) KYNU;MAOA;CYP1B1;...
Glycosaminoglycan degradation 1.71 2.77e-2 19/19 (100%) HGSNAT;GLB1;HEXA;...
Phenylalanine metabolism 1.70 2.76e-2 14/17 (82.35%) MAOA;ALDH3B1;ALDH3A1
Drug metabolism 1.66 3.84e-2 78/151 (51.66%) MAOA;GSTM3;GSTA1;...
Glyoxylate and dicarboxylate metabolism 1.64 4.29e-2 23/30 (76.67%) GLUL;CAT;AMT;...
Histidine metabolism 1.63 4.39e-2 16/22 (72.73%) MAOA;ALDH3B1;ALDH3A1;...
Antigen processing and presentation 1.61 4.94e-2 60/78 (76.92%) TAPBP;HLA-B;HSPA1A;...
Mitophagy 1.60 4.96e-2 56/68 (82.35%) GABARAPL1;NBR1;CITED2;...
beta-Alanine metabolism 1.60 4.89e-2 25/30 (83.33%) ALDH3B1;ALDH3A1;ALDH2;...
Progesterone-mediated oocyte maturation -1.89 2.27e-2 75/100 (75%) AKT1;RPS6KA3;RPS6KA1;...
Cell cycle -1.92 1.89e-2 110/124 (88.71%) SMAD4;ESPL1;STAG1;...
DNA replication -2.13 0.00e+0 34/36 (94.44%) MCM4;RFC3;LIG1;...
Ribosome biogenesis in eukaryotes -2.17 0.00e+0 52/108 (48.15%) SNU13;HEATR1;GNL3L;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H