Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN8QAF)

• Drug Name: 8-aminoquinolines Drug Info
• Synonyms: Hexamethonium; hexamethonium; Hexonium; Benzohexamethonium; Hexamethonum; Bistrium; Hexanium; 60-26-4; UNII-3C9PSP36Z2; Esametonio [Italian]; CHEMBL100622; CHEBI:5700; 3C9PSP36Z2; N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium; NCGC00163239-01; Hexane-1,6-bis(trimethylammonium); 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-; DSSTox_RID_80651; DSSTox_CID_25053; DSSTox_GSID_45053; BRN 1760389; Esametonio; CHEMBL332524; CAS-60-26-4; Hexamethonium [INN]; Ammonium, hexamethylenebis(trimethyl-; trimethyl-[6-(trimethylazaniumyl)hexyl]azanium
• Cross-matching ID:
  PubChem CID: 3604
  ChEBI ID: CHEMBL5700
  CAS Number: CAS 60-26-4
  TTD Drug ID: D0YN5P

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Biosynthesis of unsaturated fatty acids	2.00	2.38e-2	21/27 (77.78%)	SCD;ELOVL2;ELOVL4;...
Fatty acid elongation	1.96	1.58e-2	19/27 (70.37%)	ELOVL2;ELOVL4;HSD17B12;...
Protein processing in endoplasmic reticulum	-1.92	2.37e-2	127/171 (74.27%)	ERO1B;ERO1A;DNAJC1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲