Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN8R2U)

• Drug Name: APD668 Drug Info
• Synonyms: 832714-46-2; APD-668; CHEMBL1775179; Isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)piperidine-1-carboxylate; isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate; 1-Piperidinecarboxylic acid,4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester; SCHEMBL389323; AOB6271; XTRUQJBVQBUKSQ-UHFFFAOYSA-N; MolPort-039-331-631; EX-A1795; BCP10207; BDBM50343442; ZINC68266967
• Cross-matching ID:
  PubChem CID: 11705608
  ChEBI ID: CHEMBL1775179
  TTD Drug ID: D0Q3ES

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.17	0.00e+0	34/36 (94.44%)	MCM4;PCNA;RFC3;...
Graft-versus-host disease	-1.71	4.18e-2	32/42 (76.19%)	IL1A;IL1B;HLA-DRA;...
Linoleic acid metabolism	-1.72	4.05e-2	21/29 (72.41%)	PLA2G12A;PLA2G6;CYP2C8;...
alpha-Linolenic acid metabolism	-1.72	4.33e-2	17/25 (68%)	PLA2G12A;PLA2G6;FADS2;...
Fatty acid degradation	-1.76	3.76e-2	40/43 (93.02%)	ADH1A;ADH1B;ACOX1;...
Mitophagy	-1.80	3.14e-2	56/68 (82.35%)	CSNK2A2;MAPK8;ATF4;...
Tryptophan metabolism	-1.82	3.14e-2	35/42 (83.33%)	DLST;CYP1B1;KYAT3;...
Metabolism of xenobiotics by cytochrome P450	-1.92	5.23e-3	49/77 (63.64%)	ALDH3A1;GSTA4;GSTT2;...
Arachidonic acid metabolism	-2.00	0.00e+0	48/61 (78.69%)	PLA2G12A;PLA2G6;CYP2C8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼