Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN8TH1)

Drug Name
GR-144053 Drug Info
Synonyms
GR-144053; CHEMBL36326; GR-144053F; GR144053; 2-[4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl]acetic acid; {4-[4-(4-Carbamimidoyl-phenyl)-piperazin-1-yl]-piperidin-1-yl}-acetic acid; GR 144053; AC1L5AAD; GTPL6587; ZINC5719; SCHEMBL6839445; CHEBI:92207; BDBM50037970; BRD-K12120659-305-01-4; {4-[4-(4-Carbamimidoyl-phenyl)-piperazin-1-yl]-piperidin-1-yl}-acetic acid (GR 144053)
Cross-matching ID
PubChem CID
173614
ChEBI ID
CHEMBL92207
TTD Drug ID
D0Y0AP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.14 0.00e+0 113/158 (71.52%) MRPL12;MRPS16;MRPS12;...
Proteasome 2.09 0.00e+0 44/46 (95.65%) PSMB5;PSMA1;PSMA6;...
DNA replication 2.08 0.00e+0 34/36 (94.44%) RFC2;POLE2;RPA3;...
Spliceosome 1.94 1.76e-3 101/150 (67.33%) LSM5;PPIE;PUF60;...
Ribosome biogenesis in eukaryotes 1.92 4.22e-3 52/108 (48.15%) NXT2;RPP38;POP4;...
Base excision repair 1.87 7.03e-3 29/33 (87.88%) APEX1;POLE2;PCNA;...
Mismatch repair 1.84 6.03e-3 22/23 (95.65%) RFC2;RPA3;PCNA;...
Protein export 1.75 1.85e-2 17/23 (73.91%) OXA1L;SRPRB;SEC61A1;...
RNA transport 1.74 1.95e-2 128/186 (68.82%) EIF5;NXT2;CLNS1A;...
Huntington disease 1.70 2.53e-2 233/306 (76.14%) ATP5MC2;PSMB5;GPX7;...
Parkinson disease 1.70 2.30e-2 176/249 (70.68%) CALML3;ATP5MC2;PSMB5;...
RNA polymerase 1.65 4.45e-2 23/31 (74.19%) POLR2L;POLR3K;POLR3B;...
Autophagy -1.72 4.86e-2 113/169 (66.86%) PPP2CB;RRAGD;MTMR4;...
Endocytosis -1.75 4.17e-2 198/252 (78.57%) PIP5K1C;GRK3;ARF6;...
Starch and sucrose metabolism -1.75 4.47e-2 25/36 (69.44%) PYGB;GPI;HK3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.76 4.13e-2 62/70 (88.57%) ATP6V0A1;RAC1;MAP2K4;...
Antigen processing and presentation -1.78 4.34e-2 60/78 (76.92%) CIITA;RFX5;HSPA8;...
Type I diabetes mellitus -1.81 3.72e-2 38/43 (88.37%) HLA-G;HLA-DPA1;HLA-DRA;...
Aldosterone-regulated sodium reabsorption -1.81 4.34e-2 34/37 (91.89%) PRKCB;PIK3CB;KCNJ1;...
Lysosome -1.95 1.86e-2 115/128 (89.84%) AP3M2;CTSL;CD63;...
Mitophagy -2.07 0.00e+0 56/68 (82.35%) FOXO3;BCL2L1;UBC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 6H, 24H