Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN9JCD)

Drug Name
VS-4718 Drug Info
Synonyms PND-1186
Cross-matching ID
PubChem CID
25073775
ChEBI ID
CHEMBL3040440
CAS Number
CAS 1061353-68-1
TTD Drug ID
D0A6VD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.04 0.00e+0 93/133 (69.92%) NDUFV2;ATP6V1D;COX5B;...
Phosphatidylinositol signaling system 1.91 2.82e-2 82/97 (84.54%) PIK3R3;PRKCB;CDS2;...
B cell receptor signaling pathway 1.85 2.35e-2 71/81 (87.65%) PIK3R3;CD81;IFITM1;...
Bacterial invasion of epithelial cells 1.85 1.76e-2 59/77 (76.62%) ILK;PIK3R3;RHOA;...
Hepatitis C 1.84 1.41e-2 139/157 (88.54%) PIK3R3;CD81;NFKBIA;...
Inositol phosphate metabolism 1.84 1.18e-2 66/73 (90.41%) PIK3C3;CDIPT;PLCB1;...
Salmonella infection 1.83 1.01e-2 198/249 (79.52%) TUBA1A;RHOB;SKP1;...
Fc gamma R-mediated phagocytosis 1.82 1.06e-2 79/97 (81.44%) PIK3R3;MARCKS;MARCKSL1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.80 1.41e-2 49/53 (92.45%) PRKCB;ATP2B4;RAB11A;...
ABC transporters 1.79 1.41e-2 37/45 (82.22%) ABCG1;DEFB1;TAP1;...
Platelet activation 1.77 1.54e-2 106/124 (85.48%) PIK3R3;VWF;PPP1R12A;...
Shigellosis 1.72 4.00e-2 180/246 (73.17%) ILK;PIK3R3;SKP1;...
Adherens junction 1.70 4.24e-2 63/71 (88.73%) ERBB2;IQGAP1;IGF1R;...
Ferroptosis -1.61 3.83e-2 36/41 (87.8%) SLC11A2;SLC39A14;ATG7;...
One carbon pool by folate -1.62 3.74e-2 15/20 (75%) DHFR;MTHFD1;TYMS;...
Ribosome biogenesis in eukaryotes -1.62 3.90e-2 52/108 (48.15%) NOP56;TCOF1;PWP2;...
Mismatch repair -1.63 3.80e-2 22/23 (95.65%) PCNA;MSH6;POLD2;...
Steroid biosynthesis -1.66 2.83e-2 19/20 (95%) HSD17B7;MSMO1;SQLE;...
Pyrimidine metabolism -1.67 2.90e-2 40/56 (71.43%) DCTPP1;DUT;PNP;...
Cysteine and methionine metabolism -1.73 1.73e-2 43/50 (86%) AMD1;DNMT1;BHMT;...
p53 signaling pathway -1.74 1.71e-2 63/73 (86.3%) STEAP3;PIDD1;SERPINE1;...
Maturity onset diabetes of the young -1.77 1.46e-2 21/26 (80.77%) SLC2A2;FOXA2;NEUROD1;...
Protein processing in endoplasmic reticulum -1.78 1.31e-2 127/171 (74.27%) SEC61A1;PLAA;STT3A;...
Nucleotide excision repair -1.80 1.41e-2 40/47 (85.11%) GTF2H4;RFC5;ERCC8;...
Glycolysis / Gluconeogenesis -1.84 8.76e-3 56/67 (83.58%) G6PC3;HKDC1;FBP2;...
Glycine, serine and threonine metabolism -1.90 3.94e-3 31/40 (77.5%) SRR;MAOA;PIPOX;...
Base excision repair -1.90 4.93e-3 29/33 (87.88%) PARP1;PCNA;APEX2;...
Cell cycle -2.04 0.00e+0 110/124 (88.71%) ANAPC13;GADD45A;TTK;...
Fanconi anemia pathway -2.14 0.00e+0 36/54 (66.67%) BRCA1;RPA1;MUS81;...
DNA replication -2.49 0.00e+0 34/36 (94.44%) PCNA;POLD2;POLE3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H