Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN9RPO)

Drug Name
Nafcillin Drug Info
Synonyms
Nafcilina; Nafcilline; Nafcillinum; Nallpen; Naphcillin; Naphthamidopenicillin; Unipen; NAFCILLIN SODIUM; Nafcillin sodium for injection; Nallpen In Plastic Container; Nafcilin-1; Nafcilina [INN-Spanish]; Nafcillin & VRC3375; Nafcillin (INN); Nafcillin [INN:BAN]; Nafcilline [INN-French]; Nafcillinum [INN-Latin]; Nafcillin, Monosodium Salt, Anhydrous; (2-Ethoxy-1-naphthyl)penicillin; (2-ethoxy-1-naphthalenyl)penicillin; (2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2-ethoxy-1-naphthamido)penicillanic acid; 6-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion; 6beta-(2-ethoxynaphthalene-1-carboxamido)-2,2-dimethylpenam-3alpha-carboxylic acid
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
8982
ChEBI ID
CHEMBL7447
CAS Number
CAS 147-52-4
TTD Drug ID
D0A0JH
VARIDT Drug ID
DR01384
ACDINA Drug ID
D01266

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 2.04 0.00e+0 60/78 (76.92%) HLA-DQA1;HSPA8;HLA-DOB;...
Viral myocarditis 1.94 0.00e+0 53/60 (88.33%) HLA-DQA1;LAMA2;HLA-DOB;...
Graft-versus-host disease 1.87 3.06e-3 32/42 (76.19%) HLA-DQA1;HLA-DOB;PRF1;...
Central carbon metabolism in cancer 1.77 3.21e-2 67/70 (95.71%) MET;PDGFRA;SIRT3;...
Glycine, serine and threonine metabolism 1.75 3.48e-2 31/40 (77.5%) MAOB;BHMT;GLDC;...
Steroid hormone biosynthesis -1.73 4.55e-2 43/61 (70.49%) SULT2B1;UGT2B4;CYP1B1;...
Vitamin digestion and absorption -1.76 4.15e-2 17/24 (70.83%) BTD;LRAT;LMBRD1;...
Fat digestion and absorption -1.76 4.92e-2 35/43 (81.4%) PLPP3;PLPP2;FABP1;...
Metabolism of xenobiotics by cytochrome P450 -1.80 2.92e-2 49/77 (63.64%) UGT2B4;MGST2;CYP1B1;...
Folate biosynthesis -1.80 4.37e-2 23/26 (88.46%) ALPP;FPGS;ALPI;...
PPAR signaling pathway -1.94 1.09e-2 66/74 (89.19%) ACSL4;ACOX3;NR1H3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H