Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMN9YOB)

Drug Name
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole Drug Info
Synonyms 4,5,6,7-tetrabromobenzotriazole
Cross-matching ID
PubChem CID
1694
ChEBI ID
CHEMBL177820
CAS Number
CAS 17374-26-4
TTD Drug ID
D0O1YH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mucin type O-glycan biosynthesis -1.67 4.95e-2 20/36 (55.56%) ST6GALNAC2;GCNT1;ST6GALNAC4;...
Steroid biosynthesis -1.69 4.75e-2 19/20 (95%) DHCR7;HSD17B7;LSS;...
Vibrio cholerae infection -1.71 4.45e-2 44/50 (88%) CFTR;PRKCA;ATP6V0A1;...
Sulfur metabolism -1.73 3.85e-2 9/10 (90%) PAPSS2;SELENBP1;ETHE1;...
Thyroid hormone synthesis -1.77 2.52e-2 66/75 (88%) SLC5A5;PRKCA;ITPR1;...
Lysosome -1.78 2.59e-2 115/128 (89.84%) GLB1;ACP2;ATP6V0D1;...
Antigen processing and presentation -1.79 3.24e-2 60/78 (76.92%) HLA-DRB1;HLA-G;HSPA8;...
ABC transporters -1.83 2.52e-2 37/45 (82.22%) ABCB6;ABCD4;ABCB9;...
Other glycan degradation -1.84 3.78e-2 13/18 (72.22%) HEXB;GLB1;MAN2B2;...
Protein processing in endoplasmic reticulum -2.10 0.00e+0 127/171 (74.27%) SKP1;LMAN1L;GANAB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM - 25uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM - 25uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 25uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM - 25uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM - 25uM 6H