Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNA9KW)

• Drug Name: CCT251545 Drug Info
• Synonyms: 1661839-45-7; 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one; CHEMBL3408213; 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one; CCT-251545; 8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl]pyridin-4-Yl}-2,8-Diazaspiro[4.5]decan-1-One; GTPL8945; SCHEMBL17113515; CHEBI:143114; AMY16654; BCP17378; EX-A2539; BDBM50073190; NSC784591; s7981; ZINC212373586; CCT 251545; CS-5359; NSC-784591; AC-31717; HY-12681; DB-119021; CCT 251545;CCT-251545; CCT-251545;CCT 251545; Q27075796; 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-; 4TV; 8-[3-Chloro-5-[4-(1-methyl-1H-pyrazole-4-yl)phenyl]-4-pyridyl]-2,8-diazaspiro[4.5]decane-1-one
• Cross-matching ID:
  PubChem CID: 77050682
  ChEBI ID: CHEMBL3408213
  TTD Drug ID: D70HIN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.03	0.00e+0	19/20 (95%)	MSMO1;DHCR7;CYP51A1;...
Ribosome biogenesis in eukaryotes	2.01	7.12e-3	52/108 (48.15%)	NOP10;HEATR1;NXT1;...
Mucin type O-glycan biosynthesis	1.87	1.19e-2	20/36 (55.56%)	GALNT1;C1GALT1;GALNT12;...
Ferroptosis	1.86	8.89e-3	36/41 (87.8%)	HMOX1;SLC7A11;SLC39A8;...
Nitrogen metabolism	1.79	2.56e-2	16/17 (94.12%)	CA12;GLUL;CA2;...
Ribosome	1.77	2.49e-2	113/158 (71.52%)	RPS5;RPL36;RPL14;...
Legionellosis	1.71	3.86e-2	51/57 (89.47%)	CXCL3;CXCL8;CXCL1;...
Cysteine and methionine metabolism	1.71	3.65e-2	43/50 (86%)	BCAT1;CBS;CTH;...
Complement and coagulation cascades	1.69	3.80e-2	76/85 (89.41%)	SERPINB2;C1QB;CFB;...
RNA polymerase	1.67	4.20e-2	23/31 (74.19%)	POLR1D;POLR3G;POLR3K;...
Focal adhesion	-1.83	4.15e-2	180/201 (89.55%)	SOS1;PIK3CD;FYN;...
Endocrine and other factor-regulated calcium reabsorpti...	-1.85	2.76e-2	49/53 (92.45%)	PRKCB;DNM2;ATP1B2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲