Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNARGO)

Drug Name
Phlorizin Drug Info
Synonyms
Phlorizin; Phloridzin; 60-81-1; Phlorhizin; Phlorizoside; Floridzin; Phlorrhizin; Phloretin 2'-glucoside; Phlorrhizen; Phloridzosid; Phlorizine; UNII-CU9S17279X; Phloretin-2'-O-beta-glucoside; AI3-19835; NSC 2833; Phloridzin dihydrate; EINECS 200-487-1; Phloretin-2'-beta-glucoside; CHEBI:8113; CHEMBL245067; IOUVKUPGCMBWBT-QNDFHXLGSA-N; CU9S17279X; 2'-(beta-D-Glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; 1-Propanone, 1-(2-(b
Cross-matching ID
PubChem CID
6072
ChEBI ID
CHEMBL245067
CAS Number
CAS 60-81-1
TTD Drug ID
D06WAL
VARIDT Drug ID
DR00950

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycerolipid metabolism -1.63 4.92e-2 44/61 (72.13%) AGPAT4;AKR1A1;LPIN2;...
Vascular smooth muscle contraction -1.64 4.79e-2 113/133 (84.96%) PPP1CA;GUCY1B1;AGT;...
Diabetic cardiomyopathy -1.67 3.61e-2 162/203 (79.8%) NDUFA6;CYBB;VDAC2;...
Prion disease -1.67 3.77e-2 209/273 (76.56%) ATF2;CAV3;NDUFS1;...
Bile secretion -1.67 3.79e-2 68/90 (75.56%) RXRA;SULT2A1;NR1H4;...
Oxidative phosphorylation -1.68 3.63e-2 93/133 (69.92%) COX10;NDUFS1;ATP6V0B;...
Thyroid hormone synthesis -1.70 3.34e-2 66/75 (88%) GPX1;ADCY7;PDIA4;...
Ascorbate and aldarate metabolism -1.70 3.65e-2 15/30 (50%) UGT2B4;UGT2B28;AKR1A1;...
Pancreatic secretion -1.70 4.01e-2 87/102 (85.29%) ADCY7;RAP1A;ATP1A3;...
Gastric acid secretion -1.72 3.67e-2 63/76 (82.89%) CCKBR;ADCY7;ATP1A3;...
African trypanosomiasis -1.73 3.54e-2 32/37 (86.49%) IL6;HBB;PLCB1;...
Mineral absorption -1.74 3.37e-2 48/60 (80%) MT2A;FTH1;ATP2B3;...
Cholesterol metabolism -1.79 1.97e-2 44/50 (88%) LDLRAP1;APOA4;APOB;...
Sulfur metabolism -1.79 2.36e-2 9/10 (90%) SELENBP1;TST;MPST;...
Arachidonic acid metabolism -1.83 1.47e-2 48/61 (78.69%) ALOX12;PLAAT3;GPX1;...
PPAR signaling pathway -1.87 1.18e-2 66/74 (89.19%) RXRA;RXRG;ACADM;...
Histidine metabolism -1.88 1.18e-2 16/22 (72.73%) HNMT;ALDH3B1;ASPA;...
Arginine and proline metabolism -2.04 0.00e+0 39/50 (78%) PYCR1;ALDH7A1;ALDH3A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H