Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNB3RP)

Drug Name
Lanatoside c Drug Info
Synonyms
lanatoside C; NSC7533; 17575-22-3; AC1NS0MC; [6-[6-[6-[[(3S,5R,8R,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2-methyloxan-3-yl]oxy-2-methyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl] acetate
Cross-matching ID
PubChem CID
656630
CAS Number
CAS 17575-22-3
TTD Drug ID
D0SL2V

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.52 0.00e+0 84/94 (89.36%) CXCL8;CCL20;CXCL1;...
Rheumatoid arthritis 2.40 0.00e+0 78/93 (83.87%) CXCL8;CCL20;CXCL1;...
Epithelial cell signaling in Helicobacter pylori infect... 2.22 0.00e+0 62/70 (88.57%) CXCL8;CXCL1;CXCL2;...
Bladder cancer 1.98 9.22e-3 40/41 (97.56%) CXCL8;THBS1;MMP9;...
Leishmaniasis 1.98 7.37e-3 67/77 (87.01%) HLA-DQA1;NFKBIA;FOS;...
TNF signaling pathway 1.94 1.23e-2 103/112 (91.96%) CCL20;CXCL1;TNFAIP3;...
FoxO signaling pathway 1.88 1.76e-2 118/131 (90.08%) GADD45B;IL6;IL7R;...
Kaposi sarcoma-associated herpesvirus infection 1.86 1.54e-2 172/193 (89.12%) CXCL8;CXCL1;CXCL2;...
ECM-receptor interaction 1.86 1.50e-2 80/88 (90.91%) THBS1;ITGAV;COL4A5;...
Phagosome 1.86 1.35e-2 118/152 (77.63%) HLA-DQA1;THBS1;ITGAV;...
NF-kappa B signaling pathway 1.85 1.34e-2 90/104 (86.54%) CXCL8;CXCL1;TNFAIP3;...
AGE-RAGE signaling pathway in diabetic complications 1.82 1.23e-2 97/100 (97%) CXCL8;IL6;COL4A5;...
Protein export 1.82 1.23e-2 17/23 (73.91%) SEC61G;SPCS1;SEC62;...
Inflammatory bowel disease 1.79 1.49e-2 58/65 (89.23%) HLA-DQA1;IL6;IL1B;...
Chemokine signaling pathway 1.76 2.13e-2 163/192 (84.9%) CXCL8;CCL20;CXCL1;...
Pertussis 1.76 2.00e-2 64/76 (84.21%) CXCL8;IL6;FOS;...
NOD-like receptor signaling pathway 1.75 2.02e-2 145/181 (80.11%) CXCL8;CXCL1;TNFAIP3;...
Lysosome 1.75 1.98e-2 115/128 (89.84%) NPC2;CTSV;SLC11A2;...
Phosphonate and phosphinate metabolism 1.72 2.46e-2 5/6 (83.33%) CHPT1;CEPT1
TGF-beta signaling pathway 1.69 3.32e-2 81/94 (86.17%) GREM1;THBS1;FST;...
Viral protein interaction with cytokine and cytokine re... 1.68 3.28e-2 84/100 (84%) CXCL8;CCL20;CXCL1;...
Ferroptosis 1.67 3.52e-2 36/41 (87.8%) SAT1;SLC39A8;FTH1;...
Small cell lung cancer 1.65 4.11e-2 90/92 (97.83%) GADD45B;NFKBIA;ITGAV;...
Oxidative phosphorylation 1.65 4.05e-2 93/133 (69.92%) COX6C;ATP6V0C;NDUFA6;...
Toll-like receptor signaling pathway 1.65 4.03e-2 94/104 (90.38%) CXCL8;IL6;NFKBIA;...
Protein digestion and absorption 1.64 4.11e-2 78/103 (75.73%) COL11A1;COL4A5;COL5A1;...
Cellular senescence 1.63 4.32e-2 139/156 (89.1%) CXCL8;GADD45B;IL6;...
Osteoclast differentiation 1.62 4.65e-2 117/127 (92.13%) NFKBIA;FOS;CTSK;...
Legionellosis 1.62 4.58e-2 51/57 (89.47%) CXCL8;CXCL1;CXCL2;...
Pyruvate metabolism -1.67 3.62e-2 41/47 (87.23%) FH;MDH2;AKR1A1;...
Valine, leucine and isoleucine degradation -1.69 3.21e-2 42/48 (87.5%) BCKDHA;AACS;IVD;...
Porphyrin and chlorophyll metabolism -1.69 3.35e-2 23/43 (53.49%) UGT2A3;ALAD;UGT2B28;...
Pentose phosphate pathway -1.70 3.39e-2 25/30 (83.33%) PFKM;DERA;ALDOB;...
One carbon pool by folate -1.72 3.28e-2 15/20 (75%) MTHFD1;SHMT1;MTHFS;...
Glyoxylate and dicarboxylate metabolism -1.76 2.32e-2 23/30 (76.67%) GLDC;MMUT;MDH2;...
Fructose and mannose metabolism -1.76 2.61e-2 30/33 (90.91%) FPGT;AKR1B1;AKR1B10;...
Histidine metabolism -1.78 2.02e-2 16/22 (72.73%) ASPA;ALDH7A1;HNMT;...
Glycine, serine and threonine metabolism -1.78 1.99e-2 31/40 (77.5%) ALDH7A1;BPGM;SRR;...
Non-homologous end-joining -1.81 1.64e-2 11/13 (84.62%) FEN1;XRCC5;MRE11;...
Ribosome biogenesis in eukaryotes -1.85 1.30e-2 52/108 (48.15%) IMP4;MDN1;PWP2;...
Pantothenate and CoA biosynthesis -1.86 1.74e-2 14/21 (66.67%) PANK3;PANK2;DPYD;...
Citrate cycle (TCA cycle) -1.93 1.49e-2 30/30 (100%) SDHA;FH;SDHB;...
Glycolysis / Gluconeogenesis -2.05 0.00e+0 56/67 (83.58%) ALDH7A1;BPGM;PFKM;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H