Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNB4XK)

Drug Name	BVD-523 Drug Info
Cross-matching ID	PubChem CID 11719003 ChEBI ID CHEMBL3590106 CAS Number CAS 869886-67-9 TTD Drug ID D01IED

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450	2.21	0.00e+0	49/77 (63.64%)	ALDH3A1;GSTA1;GSTP1;...
Oxidative phosphorylation	2.05	0.00e+0	93/133 (69.92%)	ATP5F1E;ATP5PD;COX7B;...
Biosynthesis of unsaturated fatty acids	2.01	0.00e+0	21/27 (77.78%)	SCD;SCP2;HSD17B4;...
Steroid biosynthesis	1.91	7.42e-3	19/20 (95%)	MSMO1;TM7SF2;HSD17B7;...
beta-Alanine metabolism	1.89	5.94e-3	25/30 (83.33%)	ALDH3A1;DPYS;ALDH6A1;...
Propanoate metabolism	1.87	8.24e-3	30/34 (88.24%)	ACAT2;ALDH6A1;EHHADH;...
Butanoate metabolism	1.86	9.89e-3	23/28 (82.14%)	ACAT2;ALDH5A1;BDH2;...
Tryptophan metabolism	1.85	1.48e-2	35/42 (83.33%)	ACAT2;KYNU;ALDH8A1;...
Herpes simplex virus 1 infection	1.84	1.43e-2	165/498 (33.13%)	BST2;BIRC3;HLA-B;...
Valine, leucine and isoleucine degradation	1.84	1.29e-2	42/48 (87.5%)	ACAT2;ALDH6A1;EHHADH;...
Steroid hormone biosynthesis	1.82	1.44e-2	43/61 (70.49%)	AKR1C3;SULT1E1;UGT2A3;...
Peroxisome	1.80	1.57e-2	72/82 (87.8%)	SCP2;AMACR;HSD17B4;...
Allograft rejection	1.78	1.67e-2	32/38 (84.21%)	HLA-B;HLA-F;CD40;...
Drug metabolism	1.78	1.55e-2	78/151 (51.66%)	ALDH3A1;GSTA1;GSTP1;...
Protein export	1.74	2.11e-2	17/23 (73.91%)	SEC11A;SRP14;SEC61B;...
Hepatitis C	1.74	2.04e-2	139/157 (88.54%)	IFIT1;E2F2;CLDN1;...
Antigen processing and presentation	1.71	2.50e-2	60/78 (76.92%)	HLA-B;HLA-F;TAP1;...
Fatty acid degradation	1.70	2.64e-2	40/43 (93.02%)	ACAT2;ADH1C;EHHADH;...
Ascorbate and aldarate metabolism	1.70	2.50e-2	15/30 (50%)	UGT2A3;AKR1A1;UGT2B28;...
Type I diabetes mellitus	1.69	2.62e-2	38/43 (88.37%)	HLA-B;HLA-F;HLA-E;...
Epstein-Barr virus infection	1.68	2.73e-2	189/202 (93.56%)	ISG15;E2F2;HLA-B;...
Phenylalanine metabolism	1.67	3.01e-2	14/17 (82.35%)	ALDH3A1;PAH;HPD;...
Ribosome	1.65	3.53e-2	113/158 (71.52%)	MRPS16;RPS26;RPS27L;...
Proximal tubule bicarbonate reclamation	1.63	3.87e-2	21/23 (91.3%)	AQP1;SLC4A4;GLUD1;...
Graft-versus-host disease	1.63	4.12e-2	32/42 (76.19%)	HLA-B;HLA-F;HLA-E;...
Tyrosine metabolism	1.62	4.15e-2	30/36 (83.33%)	ALDH3A1;ADH1C;TYRP1;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1.62	4.14e-2	20/26 (76.92%)	PIGP;PIGZ;PIGT;...
Hematopoietic cell lineage	-1.83	2.02e-2	90/99 (90.91%)	DNTT;IL1B;CD37;...
Spliceosome	-1.90	1.68e-2	101/150 (67.33%)	HSPA1A;EIF4A3;PCBP1;...
Ribosome biogenesis in eukaryotes	-2.23	0.00e+0	52/108 (48.15%)	NXF3;POP1;RRP7A;...
DNA replication	-2.28	0.00e+0	34/36 (94.44%)	RPA2;MCM2;POLA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H