Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNDOLZ)

Drug Name
naltriben Drug Info
Synonyms
Naltrindole benzofuran; Naltriben; naltrindole benzofuran; 4,8-Methano-5H-bisbenzofuro(3,2-e:2',3'-g)isoquinoline-1,8a(9H)-diol, 7-(cyclopropylmethyl)-6,7,8,14b-tetrahydro-, (8R-(4bS*,8alpha,8beta,14bbeta))-; 111555-58-9; C26H25NO4; [3H]naltriben; [3H]-naltriben; NTB; naltrindolebenzofuran; GTPL1640; SCHEMBL1240717; CHEMBL100940; GTPL3828; BDBM82552; HMS2089G18; ZINC3874478; PDSP2_001551; LS-172157; CAS_111555-58-9; C20166; AB00691672-07; naltrindole benzofuran
Cross-matching ID
PubChem CID
5486827
ChEBI ID
CHEMBL100940
CAS Number
CAS 111555-58-9
TTD Drug ID
D05ANN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
mTOR signaling pathway 2.09 0.00e+0 114/154 (74.03%) ATP6V1B2;IGF1R;SEH1L;...
Aldosterone-regulated sodium reabsorption 2.05 0.00e+0 34/37 (91.89%) HSD11B2;IGF1;FXYD2;...
Ribosome biogenesis in eukaryotes 1.93 9.62e-3 52/108 (48.15%) NXF1;CSNK2B;RCL1;...
Cell cycle 1.85 1.20e-2 110/124 (88.71%) SMC1A;CDKN1B;SMAD2;...
Signaling pathways regulating pluripotency of stem cell... 1.82 1.54e-2 110/143 (76.92%) BMP4;ID4;SMAD2;...
Allograft rejection -1.81 4.84e-2 32/38 (84.21%) HLA-DQB1;IL5;HLA-E;...
Autoimmune thyroid disease -1.85 3.63e-2 46/53 (86.79%) IFNA21;CD86;IL4;...
Graft-versus-host disease -1.96 2.07e-2 32/42 (76.19%) HLA-DQB1;KIR2DL1;IL6;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H