Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNE1FR)

Drug Name
Resminostat Drug Info
Synonyms
Resminostat; 864814-88-0; 4SC-201; RAS2410; Resminostat (RAS2410); UNII-1578EUB98L; (E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide; BYK408740; 1578EUB98L; Resminostat [INN]; 4SC 201; Resminostat 4SC-201; Resminostat (4SC-201); SCHEMBL295541; SCHEMBL295540; GTPL7502; EX-A542; DTXSID50235587; MolPort-027-720-936; AOB87187; BCP02538; 4SC201; ZINC13983495; s2693; AKOS030526945; SB16667; DB12392; CS-1521; API0013984; BC261895
Cross-matching ID
PubChem CID
11609955
ChEBI ID
CHEMBL4296717
CAS Number
CAS 864814-88-0
TTD Drug ID
D01UXJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Retinol metabolism 2.01 9.90e-3 41/68 (60.29%) ADH1B;AOX1;CYP26B1;...
Metabolism of xenobiotics by cytochrome P450 1.99 9.90e-3 49/77 (63.64%) GSTA4;ADH1B;MGST3;...
Mineral absorption 1.93 9.90e-3 48/60 (80%) MT1X;ATP1A1;STEAP1;...
Fructose and mannose metabolism 1.92 7.43e-3 30/33 (90.91%) AKR1B10;ALDOC;AKR1B1;...
Aldosterone-regulated sodium reabsorption 1.90 9.90e-3 34/37 (91.89%) SCNN1A;ATP1A1;SGK1;...
Steroid hormone biosynthesis 1.82 1.98e-2 43/61 (70.49%) AKR1C3;AKR1C2;SRD5A1;...
Pentose and glucuronate interconversions 1.81 1.70e-2 17/34 (50%) AKR1B10;AKR1B1;UGT2B15;...
Complement and coagulation cascades 1.80 1.86e-2 76/85 (89.41%) CFD;PLAT;TFPI;...
Glycerolipid metabolism 1.80 1.65e-2 44/61 (72.13%) AKR1B10;AKR1B1;PLPP2;...
Sulfur metabolism 1.74 3.17e-2 9/10 (90%) PAPSS1;PAPSS2;ETHE1;...
Galactose metabolism 1.72 3.15e-2 26/31 (83.87%) AKR1B10;AKR1B1;PFKM;...
Oxidative phosphorylation 1.71 3.55e-2 93/133 (69.92%) ATP6V1A;PPA1;NDUFB3;...
Cardiac muscle contraction 1.71 3.28e-2 64/87 (73.56%) ATP1A1;ASPH;CACNA2D2;...
Glycolysis / Gluconeogenesis 1.71 3.25e-2 56/67 (83.58%) ALDOC;ADH1B;PFKM;...
Pentose phosphate pathway 1.69 3.76e-2 25/30 (83.33%) ALDOC;PFKM;ALDOB;...
Synaptic vesicle cycle 1.69 3.59e-2 63/78 (80.77%) SLC1A1;SYT1;STXBP1;...
Ether lipid metabolism 1.66 4.19e-2 32/49 (65.31%) PLAAT3;PLA2G2A;PLPP2;...
Selenocompound metabolism 1.64 4.73e-2 11/17 (64.71%) PAPSS1;PAPSS2;TXNRD1;...
Lysosome 1.63 4.85e-2 115/128 (89.84%) LIPA;GM2A;AP1S2;...
PPAR signaling pathway 1.63 4.60e-2 66/74 (89.19%) FABP7;PLIN2;ME1;...
Apoptosis -1.67 4.88e-2 126/168 (75%) HRAS;CTSZ;IL3RA;...
Fanconi anemia pathway -1.73 3.28e-2 36/54 (66.67%) BRCA2;FANCG;BRIP1;...
Cell cycle -1.76 2.54e-2 110/124 (88.71%) CDC6;PCNA;ABL1;...
One carbon pool by folate -1.77 2.90e-2 15/20 (75%) DHFR;FTCD;MTHFD2;...
Chronic myeloid leukemia -1.80 2.54e-2 72/76 (94.74%) HRAS;STAT5B;ABL1;...
Herpes simplex virus 1 infection -1.82 2.85e-2 165/498 (33.13%) TRAF6;TSC2;CD74;...
Ribosome biogenesis in eukaryotes -1.85 2.54e-2 52/108 (48.15%) REXO2;POP4;GNL2;...
DNA replication -1.89 1.36e-2 34/36 (94.44%) POLD3;PCNA;RPA2;...
Cytosolic DNA-sensing pathway -1.95 1.02e-2 52/63 (82.54%) AIM2;NFKBIB;POLR3D;...
Spliceosome -2.01 1.02e-2 101/150 (67.33%) SNRNP200;TRA2A;SNRPA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H