Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNFUZR)

Drug Name
Enalapril Drug Info
Synonyms
Vasotec; Enalapril (INN); Enalapril (TN); N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline; N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
5388962
ChEBI ID
CHEMBL578
CAS Number
CAS 75847-73-3
TTD Drug ID
D00SEB
VARIDT Drug ID
DR00010
INTEDE Drug ID
DR0573
ACDINA Drug ID
D00229

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oocyte meiosis 2.10 0.00e+0 90/129 (69.77%) PPP3CA;PLK1;MAPK13;...
Progesterone-mediated oocyte maturation 2.08 0.00e+0 75/100 (75%) PLK1;MAPK13;CCNA2;...
Mismatch repair 1.87 2.32e-2 22/23 (95.65%) RFC2;POLD2;RPA2;...
RNA degradation 1.84 4.07e-2 53/79 (67.09%) PAN2;TOB1;PFKP;...
DNA replication 1.82 3.25e-2 34/36 (94.44%) RFC2;RNASEH2A;POLA2;...
Purine metabolism 1.79 3.29e-2 102/129 (79.07%) PDE4B;PKM;PDE10A;...
Type II diabetes mellitus 1.78 3.15e-2 42/46 (91.3%) PKM;IRS1;MAPK1;...
VEGF signaling pathway 1.76 2.91e-2 50/59 (84.75%) PPP3CA;BAD;MAPK13;...
Legionellosis -1.79 2.89e-2 51/57 (89.47%) CYCS;ITGB2;IL6;...
IL-17 signaling pathway -1.81 3.03e-2 84/94 (89.36%) DEFB4A;MAP3K7;CXCL6;...
PPAR signaling pathway -1.84 3.72e-2 66/74 (89.19%) PLIN2;APOC3;FABP3;...
Retinol metabolism -1.92 3.31e-2 41/68 (60.29%) UGT2B4;AOX1;DGAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H