General Information of Drug (ID: DMNHM1B)

Drug Name
AMG-837 Drug Info
Synonyms AMG 837; AMG837
Cross-matching ID
PubChem CID
46854655
ChEBI ID
CHEMBL1829173
CAS Number
CAS 865231-46-5
TTD Drug ID
D0Q7BG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Type I diabetes mellitus -1.89 7.81e-4 38/43 (88.37%) HLA-B;HLA-C;HLA-F;...
Kaposi sarcoma-associated herpesvirus infection -1.91 4.31e-4 172/193 (89.12%) MAPK3;RAF1;MAPKAPK2;...
T cell receptor signaling pathway -1.91 4.46e-4 93/104 (89.42%) MAPK3;RAF1;MAP3K8;...
Intestinal immune network for IgA production -1.93 4.63e-4 38/48 (79.17%) HLA-DMB;CXCR4;CD80;...
Pertussis -1.93 4.81e-4 64/76 (84.21%) ITGB1;MAPK3;CALML4;...
Systemic lupus erythematosus -1.94 5.00e-4 45/135 (33.33%) C2;C1QB;HLA-DQB1;...
Inflammatory bowel disease -1.97 5.21e-4 58/65 (89.23%) RORC;RORA;IL18RAP;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.99 0.00e+0 79/89 (88.76%) JAK2;TLR2;CSNK2A2;...
Primary immunodeficiency -2.00 0.00e+0 33/38 (86.84%) RFXANK;TAP1;ZAP70;...
NOD-like receptor signaling pathway -2.02 0.00e+0 145/181 (80.11%) TYK2;CASP8;TRAF3;...
Neutrophil extracellular trap formation -2.03 0.00e+0 101/189 (53.44%) SELP;SIGLEC9;MAPK3;...
Lipid and atherosclerosis -2.08 0.00e+0 190/215 (88.37%) PLCG1;IL18;CD14;...
Autoimmune thyroid disease -2.09 0.00e+0 46/53 (86.79%) HLA-B;HLA-C;HLA-F;...
Asthma -2.09 0.00e+0 25/31 (80.65%) RNASE3;HLA-DQB1;HLA-DPB1;...
Allograft rejection -2.10 0.00e+0 32/38 (84.21%) HLA-B;HLA-C;HLA-F;...
Coronavirus disease -2.10 0.00e+0 215/232 (92.67%) RPL3L;IFNA6;RPL18;...
Staphylococcus aureus infection -2.10 0.00e+0 72/95 (75.79%) CFB;FCGR2C;KRT32;...
Epithelial cell signaling in Helicobacter pylori infect... -2.11 0.00e+0 62/70 (88.57%) PLCG1;PAK1;ATP6V1E1;...
Amoebiasis -2.13 0.00e+0 99/102 (97.06%) CD1E;ARG2;CD1B;...
Legionellosis -2.13 0.00e+0 51/57 (89.47%) IL18;CD14;IL1B;...
TNF signaling pathway -2.14 0.00e+0 103/112 (91.96%) SELE;IL1B;FOS;...
Antigen processing and presentation -2.15 0.00e+0 60/78 (76.92%) KIR2DL4;HSPA6;PSME1;...
Chemokine signaling pathway -2.16 0.00e+0 163/192 (84.9%) ADCY7;NFKBIA;CCL22;...
Hematopoietic cell lineage -2.29 0.00e+0 90/99 (90.91%) CD1B;IL6;ITGA2B;...
Th1 and Th2 cell differentiation -2.32 0.00e+0 80/92 (86.96%) JAK2;IL2RA;ZAP70;...
NF-kappa B signaling pathway -2.35 0.00e+0 90/104 (86.54%) BCL2A1;CSNK2A2;ZAP70;...
Graft-versus-host disease -2.38 0.00e+0 32/42 (76.19%) HLA-B;HLA-C;HLA-F;...
IL-17 signaling pathway -2.50 0.00e+0 84/94 (89.36%) IL1B;S100A7;FOS;...
Viral protein interaction with cytokine and cytokine re... -2.55 0.00e+0 84/100 (84%) CCL24;CXCL6;CXCR3;...
Rheumatoid arthritis -2.68 0.00e+0 78/93 (83.87%) HLA-DQB1;ATP6V1E1;IL18;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H