Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNHTZI)

• Drug Name: Protriptyline Drug Info
• Synonyms: Amimetilina; Impril; Maximed; Novopramine; Protriptilina; Protriptylinum; Protryptyline; Rhotrimine; Triptil; Triptyl; Vivactil; Vivactyl; Triptil hydrochloride; Normethyl EX4442; Triadapin 5; Apo-Imipramine; Apo-Trimip; Novo-Doxepin; Novo-Tripramine; Protriptilina [INN-Spanish]; Protriptyline (INN); Protriptyline [INN:BAN]; Protriptylinum [INN-Latin]; Vivactil (TN); N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine; N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine; 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine; 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine; 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene; 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene; 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 4976
  ChEBI ID: CHEMBL668
  CAS Number: CAS 438-60-8
  TTD Drug ID: D00MYQ
  VARIDT Drug ID: DR00486
  ACDINA Drug ID: D00567

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.37	0.00e+0	19/20 (95%)	MSMO1;LSS;DHCR24;...
Lysosome	2.04	4.23e-3	115/128 (89.84%)	NPC2;GALC;CTSK;...
Pentose phosphate pathway	1.94	5.63e-3	25/30 (83.33%)	ALDOC;PFKP;GPI;...
Steroid hormone biosynthesis	1.93	4.23e-3	43/61 (70.49%)	HSD17B7;SRD5A1;STS;...
Terpenoid backbone biosynthesis	1.92	5.07e-3	18/22 (81.82%)	HMGCS1;FDPS;IDI1;...
Amino sugar and nucleotide sugar metabolism	1.89	7.04e-3	38/48 (79.17%)	GNPDA1;GNE;GPI;...
Other glycan degradation	1.83	1.45e-2	13/18 (72.22%)	NEU1;HEXA;MAN2C1;...
Mucin type O-glycan biosynthesis	1.81	1.48e-2	20/36 (55.56%)	GCNT3;GALNT12;GALNT3;...
Galactose metabolism	1.80	1.50e-2	26/31 (83.87%)	PFKP;GALT;PGM1;...
Biosynthesis of unsaturated fatty acids	1.80	1.35e-2	21/27 (77.78%)	SCD;FADS1;ELOVL6;...
Butanoate metabolism	1.79	1.46e-2	23/28 (82.14%)	HMGCS1;ACAT2;ABAT;...
Synaptic vesicle cycle	1.78	1.41e-2	63/78 (80.77%)	STX1A;CLTA;UNC13B;...
Inositol phosphate metabolism	1.78	1.30e-2	66/73 (90.41%)	PIP5K1B;PI4KA;CDIPT;...
Central carbon metabolism in cancer	1.68	3.68e-2	67/70 (95.71%)	IDH1;PFKP;ERBB2;...
Fatty acid elongation	1.66	4.34e-2	19/27 (70.37%)	ELOVL6;ELOVL5;PPT1;...
Glyoxylate and dicarboxylate metabolism	1.66	4.12e-2	23/30 (76.67%)	ACAT2;ACO1;GLDC;...
Basal transcription factors	-1.91	1.89e-2	37/45 (82.22%)	ERCC3;TBP;TAF7;...
Spliceosome	-2.04	2.52e-2	101/150 (67.33%)	CRNKL1;RBM25;RBMX;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼