Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNLD6E)

Drug Name
CP55,667 Drug Info
Synonyms CP 55,667; CP-55,667
Cross-matching ID
PubChem CID
4412255
ChEBI ID
CHEMBL77520
TTD Drug ID
D0X3TF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.01 1.25e-2 80/88 (90.91%) SV2A;VWF;COL6A3;...
Amoebiasis 1.87 3.33e-2 99/102 (97.06%) CXCL8;GNAS;ARG2;...
DNA replication -1.73 4.61e-2 34/36 (94.44%) LIG1;MCM2;RFC3;...
Sulfur metabolism -1.77 3.78e-2 9/10 (90%) MPST;TST;PAPSS2;...
Base excision repair -1.91 4.80e-3 29/33 (87.88%) MBD4;PARP2;POLB;...
Pyruvate metabolism -1.96 3.60e-3 41/47 (87.23%) ADH5;HAGH;ADH1A;...
Oxidative phosphorylation -1.99 7.20e-3 93/133 (69.92%) ATP5F1D;COX7A2L;NDUFA5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H