Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNLHAC)

Drug Name
Allopregnanolone Drug Info
Synonyms
516-54-1; Brexanolone; Allotetrahydroprogesterone; Allopregnan-3alpha-ol-20-one; 3alpha-hydroxy-5alpha-pregnan-20-one; SAGE-547; UNII-S39XZ5QV8Y; 3-alpha,5-alpha-Pregnanolone; 3alpha-OH DHP; 3alpha,5alpha-THP; 5alpha-Pregnan-3alpha-ol-20-one; 3a-Hydroxy-5a-pregnan-20-one; 3a,5a-THP; (3alpha)-Allopregnanolone; 3-alpha,5-alpha-Tetrahydroprogesterone; BRN 3211363; S39XZ5QV8Y; 3alpha-Hydroxy-5alpha-dihydroprogesterone; 3-alpha-Hydroxy-5-alpha-pregnan-20-one; CHEMBL207538; CHEBI:50169; SGE-102
Cross-matching ID
PubChem CID
92786
ChEBI ID
CHEMBL207538
CAS Number
CAS 516-54-1
TTD Drug ID
D00VZZ
INTEDE Drug ID
DR0226
ACDINA Drug ID
D00891

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.86 3.79e-2 52/108 (48.15%) NAT10;FBL;NHP2;...
Galactose metabolism 1.78 4.74e-2 26/31 (83.87%) GLA;AKR1B1;PFKM;...
Phototransduction 1.73 4.42e-2 21/29 (72.41%) CALML5;CALML3;CALML4;...
Aminoacyl-tRNA biosynthesis 1.71 4.68e-2 15/66 (22.73%) FARSA;GATB;SARS2;...
MicroRNAs in cancer -1.76 2.84e-2 146/310 (47.1%) SIRT1;MAP2K1;BMPR2;...
Collecting duct acid secretion -1.76 2.60e-2 22/27 (81.48%) ATP6V0D1;ATP6V1F;CLCNKB;...
mTOR signaling pathway -1.79 2.47e-2 114/154 (74.03%) BRAF;PRKCB;AKT1;...
NF-kappa B signaling pathway -1.80 2.11e-2 90/104 (86.54%) BCL2L1;PLCG2;BIRC2;...
TNF signaling pathway -1.83 1.23e-2 103/112 (91.96%) CCL20;JUN;FAS;...
Aldosterone-regulated sodium reabsorption -1.86 7.40e-3 34/37 (91.89%) MAPK1;PDPK1;ATP1A1;...
Autophagy -1.87 6.17e-3 113/169 (66.86%) MAPK1;BCL2L1;PDPK1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.90 8.22e-3 62/70 (88.57%) GIT1;ATP6V0D1;ATP6V1F;...
Complement and coagulation cascades -1.91 1.23e-2 76/85 (89.41%) PLAT;CFH;C7;...
Renal cell carcinoma -1.96 0.00e+0 68/69 (98.55%) SOS1;BRAF;AKT1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H