Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNMG0I)

Drug Name
CGP 55845 Drug Info
Synonyms CGP55845; CGP-55845A; CGP-55845
Cross-matching ID
PubChem CID
5311042
ChEBI ID
CHEMBL91949
CAS Number
CAS 150175-54-5
TTD Drug ID
D09QOE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.95 0.00e+0 110/124 (88.71%) CDC20;PCNA;PLK1;...
DNA replication 1.88 8.15e-3 34/36 (94.44%) PCNA;RPA3;MCM4;...
Mismatch repair 1.84 1.90e-2 22/23 (95.65%) PCNA;RPA3;MSH6;...
Circadian entrainment 1.83 2.04e-2 85/97 (87.63%) GUCY1A1;GNG11;GNAQ;...
Nucleotide excision repair 1.75 3.91e-2 40/47 (85.11%) PCNA;RPA3;POLE2;...
Alcoholism 1.70 4.66e-2 86/186 (46.24%) NTRK2;HAT1;NPY;...
Butanoate metabolism 1.70 4.38e-2 23/28 (82.14%) ACAT2;BDH2;ABAT;...
Glycine, serine and threonine metabolism -1.78 4.08e-2 31/40 (77.5%) GCAT;AMT;PIPOX;...
Rheumatoid arthritis -1.86 2.10e-2 78/93 (83.87%) IL23A;TGFB2;MMP1;...
Metabolism of xenobiotics by cytochrome P450 -2.00 0.00e+0 49/77 (63.64%) EPHX1;GSTM5;GSTA1;...
Retinol metabolism -2.17 0.00e+0 41/68 (60.29%) RDH16;RETSAT;CYP1A2;...
Steroid hormone biosynthesis -2.28 0.00e+0 43/61 (70.49%) CYP1A2;HSD17B6;UGT2B28;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H