Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNMW9R)

• Drug Name: Pramipexole Drug Info
• Synonyms: Mirapex; Pramipexol; Pramipexolum; SUD919CL2Y; Mirapex (TN); Mirapexin (TN); Pramipexole [USAN:INN]; SND-919; Sifrol(TN); U-98528E; Pramipexole (USAN/INN); (-)-Pramipexole; (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole; 111GE001; 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole; 2-amino-6-propylaminotetrahydrobenzothiazole
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 119570
  ChEBI ID: CHEMBL301265
  CAS Number: CAS 104632-26-0
  TTD Drug ID: D0G8NN
  VARIDT Drug ID: DR00620
  ACDINA Drug ID: D00546

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.48	0.00e+0	34/36 (94.44%)	RFC2;MCM5;LIG1;...
Mismatch repair	2.31	0.00e+0	22/23 (95.65%)	RFC2;MSH2;LIG1;...
IL-17 signaling pathway	2.16	3.14e-3	84/94 (89.36%)	CXCL5;LCN2;CXCL8;...
TNF signaling pathway	1.93	7.07e-3	103/112 (91.96%)	CASP10;CXCL5;CXCL1;...
Cell cycle	1.90	5.66e-3	110/124 (88.71%)	CDC20;BUB1;WEE1;...
Homologous recombination	1.86	9.43e-3	35/41 (85.37%)	BLM;RAD51;BARD1;...
Nucleotide excision repair	1.86	8.08e-3	40/47 (85.11%)	RFC2;LIG1;POLE2;...
Base excision repair	1.83	9.43e-3	29/33 (87.88%)	HMGB1;LIG1;POLE2;...
Thiamine metabolism	1.81	9.43e-3	12/15 (80%)	AK4;TPK1;AK5
NF-kappa B signaling pathway	1.76	2.36e-2	90/104 (86.54%)	CXCL8;CXCL1;LYN;...
Primary bile acid biosynthesis	1.74	2.83e-2	15/17 (88.24%)	CH25H;CYP46A1;SCP2;...
Mucin type O-glycan biosynthesis	1.70	3.69e-2	20/36 (55.56%)	GALNT6;GALNT7;GALNT1;...
Oocyte meiosis	1.69	3.92e-2	90/129 (69.77%)	CDC20;BUB1;SMC1A;...
Fanconi anemia pathway	1.69	3.90e-2	36/54 (66.67%)	BLM;HES1;USP1;...
Hepatitis B	1.68	3.77e-2	151/162 (93.21%)	CASP10;CXCL8;TGFBR2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	1.66	4.65e-2	79/89 (88.76%)	RASGRP1;JAK1;EML4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	15uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼