Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNO38U)

Drug Name
Bortezomib Drug Info
Synonyms
179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
387447
ChEBI ID
CHEMBL325041
CAS Number
CAS 179324-69-7
TTD Drug ID
D0SH3I
VARIDT Drug ID
DR01331
INTEDE Drug ID
DR0221

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.48 0.00e+0 127/171 (74.27%) HSPA6;HSPA1A;DNAJB1;...
Mineral absorption 2.11 0.00e+0 48/60 (80%) HMOX1;MT1M;MT1E;...
Legionellosis 2.10 0.00e+0 51/57 (89.47%) HSPA6;HSPA1A;HSPA8;...
Antigen processing and presentation 2.05 0.00e+0 60/78 (76.92%) HSPA6;HSPA1A;HSPA8;...
Spliceosome 2.04 0.00e+0 101/150 (67.33%) HSPA6;HSPA1A;HSPA8;...
IL-17 signaling pathway 1.95 1.53e-3 84/94 (89.36%) MMP1;CXCL8;HSP90AB1;...
Lipid and atherosclerosis 1.79 1.71e-2 190/215 (88.37%) HSPA6;HSPA1A;MMP1;...
Protein export 1.79 1.49e-2 17/23 (73.91%) HSPA5;SEC62;SEC63;...
RNA transport 1.75 2.04e-2 128/186 (68.82%) FXR1;NXF1;EIF5;...
Longevity regulating pathway 1.75 1.84e-2 90/151 (59.6%) HSPA6;HSPA1A;HSPA8;...
Ferroptosis 1.74 1.92e-2 36/41 (87.8%) HMOX1;SLC7A11;TFRC;...
Estrogen signaling pathway 1.67 4.06e-2 119/137 (86.86%) HSPA6;HSPA1A;HSPA8;...
Arachidonic acid metabolism -1.67 4.44e-2 48/61 (78.69%) ALOX15B;PLA2G4C;HPGDS;...
Valine, leucine and isoleucine degradation -1.67 4.68e-2 42/48 (87.5%) DLD;ALDH1B1;PCCA;...
Tryptophan metabolism -1.71 3.30e-2 35/42 (83.33%) GCDH;CYP1A1;TDO2;...
Oocyte meiosis -1.71 3.58e-2 90/129 (69.77%) ANAPC1;RPS6KA1;PRKACA;...
Nucleotide excision repair -1.73 3.61e-2 40/47 (85.11%) CUL4B;RAD23B;XPA;...
Cell cycle -1.74 3.54e-2 110/124 (88.71%) CDK6;ATM;CDC20;...
Steroid hormone biosynthesis -1.76 3.70e-2 43/61 (70.49%) UGT2B4;UGT2B28;CYP1A1;...
Histidine metabolism -1.81 1.88e-2 16/22 (72.73%) MAOB;HNMT;ALDH1B1;...
Pyrimidine metabolism -1.82 2.15e-2 40/56 (71.43%) DHODH;TK2;UCK2;...
beta-Alanine metabolism -1.83 2.32e-2 25/30 (83.33%) ALDH1B1;MLYCD;ECHS1;...
Base excision repair -1.84 2.79e-2 29/33 (87.88%) NEIL1;PARP2;HMGB1;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.85 3.22e-2 9/11 (81.82%) VKORC1;NQO1;TAT;...
Metabolism of xenobiotics by cytochrome P450 -1.88 1.43e-2 49/77 (63.64%) GSTK1;UGT2B4;UGT2B28;...
DNA replication -2.02 0.00e+0 34/36 (94.44%) MCM4;RNASEH1;MCM6;...
Drug metabolism -2.03 0.00e+0 78/151 (51.66%) GSTK1;UGT2B4;TK2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.04uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 20uM 24H
TC-32 CVCL_7141 Homo sapiens 20uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 0.125uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 20uM 24H
YH-13 CVCL_1800 Homo sapiens 20uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 50uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 20uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 20uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 20uM 24H
T-47D CVCL_0553 Homo sapiens 20uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 20uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 20uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 20uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.04uM 6H
GP2d CVCL_1234 Homo sapiens 20uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 20uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.04uM 6H
MDST8 CVCL_1400 Homo sapiens 0.04uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.04uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.04uM 6H
SNU-407 CVCL_5004 Homo sapiens 20uM 24H
SNU-C4 CVCL_5008 Homo sapiens 0.04uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.04uM 6H
SW480 CVCL_0546 Homo sapiens 0.04uM 6H
SW620 CVCL_0547 Homo sapiens 0.04uM 6H
SW948 CVCL_0550 Homo sapiens 0.04uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.04uM 6H
HT115 CVCL_1294 Homo sapiens 0.04uM 6H
RKO CVCL_0504 Homo sapiens 0.04uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.04uM - 20uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 20uM 24H
HEC-1-A CVCL_0293 Homo sapiens 20uM 24H
HEC-251 CVCL_2928 Homo sapiens 20uM 24H
HEC-265 CVCL_2929 Homo sapiens 20uM 24H
SNG-M CVCL_1707 Homo sapiens 0.04uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.04uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 20uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 20uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 20uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 20uM 24H
JHH-7 CVCL_1322 Homo sapiens 20uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 20uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 0.04uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 20uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 20uM 24H
NCI-H838 CVCL_1594 Homo sapiens 20uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 0.04uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.04uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.04uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.04uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 20uM 24H
HCC15 CVCL_1253 Homo sapiens 0.04uM 6H
HCC1588 CVCL_1263 Homo sapiens 20uM 24H
HCC95 CVCL_1276 Homo sapiens 20uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.04uM 6H
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.04uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 20uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 20uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.04uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.04uM 6H
NCI-H841 CVCL_1595 Homo sapiens 20uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 4H, 6H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 0.04uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 20uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 20uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.04uM 6H
OV7 CVCL_1623 Homo sapiens 0.04uM 6H
OVK18 CVCL_1629 Homo sapiens 20uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 20uM 24H
OVTOKO CVCL_3114 Homo sapiens 20uM 24H
RMG-I CVCL_1663 Homo sapiens 0.04uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 20uM 24H
OC 316 CVCL_1615 Homo sapiens 20uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 20uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 20uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.04uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.04uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.04uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 20uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 20uM 3H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.04uM 6H
PL-21 CVCL_2161 Homo sapiens 0.04uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.04uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 20uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.04uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 20uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 20uM 24H
PC-3 CVCL_0035 Homo sapiens 0.002uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 20uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 20uM 24H
Mel-HO CVCL_1402 Homo sapiens 20uM 24H
SH-4 CVCL_1692 Homo sapiens 20uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.04uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.04uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 20uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.04uM - 20uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 20uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 20uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 20uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 20uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 20uM 24H