Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNP60F)

• Drug Name: Anastrozole Drug Info
• Synonyms: Anastrazole; Anastrole; Anastrozol; Arimidex; Asiolex; Astra brand of anastrozole; AstraZeneca brand of anastrozole; Zeneca brand of anastrozole; ZD 1033; ZD1033; Zeneca ZD 1033; Arimidex (TN); Arimidex (Zeneca); Arimidex, Anastrozole; ZD-1033; Anastrozole [USAN:INN:BAN]; Anastrozole (JAN/USAN/INN); Alpha,alpha,alpha',alpha'-tetramethyl-5(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile; Alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile; 1,3-benzenediacetonitrile, a, a,a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl); 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile); 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile); 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile); 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 2187
  ChEBI ID: CHEMBL1399
  CAS Number: CAS 120511-73-1
  TTD Drug ID: D0W0BF
  VARIDT Drug ID: DR00464
  INTEDE Drug ID: DR0113
  ACDINA Drug ID: D00039

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Citrate cycle (TCA cycle)	2.17	0.00e+0	30/30 (100%)	DLD;IDH1;IDH3A;...
DNA replication	2.08	0.00e+0	34/36 (94.44%)	FEN1;MCM3;MCM7;...
Propanoate metabolism	2.08	0.00e+0	30/34 (88.24%)	DLD;ABAT;PCCB;...
Valine, leucine and isoleucine degradation	2.05	3.04e-3	42/48 (87.5%)	DLD;ABAT;HMGCS1;...
Morphine addiction	2.03	2.43e-3	80/91 (87.91%)	PRKCA;PRKACB;GNG11;...
Aldosterone-regulated sodium reabsorption	1.92	8.11e-3	34/37 (91.89%)	PRKCA;FXYD2;MAPK1;...
Glyoxylate and dicarboxylate metabolism	1.90	8.69e-3	23/30 (76.67%)	DLD;PCCB;ACO1;...
Cell cycle	1.89	7.60e-3	110/124 (88.71%)	CDKN2C;MCM3;CCNA2;...
Phosphatidylinositol signaling system	1.83	1.49e-2	82/97 (84.54%)	PRKCA;ITPR1;PI4KA;...
Progesterone-mediated oocyte maturation	1.82	1.58e-2	75/100 (75%)	PRKACB;GNAI1;HSP90AA1;...
Circadian entrainment	1.81	1.66e-2	85/97 (87.63%)	CREB1;PRKCA;ITPR1;...
Type II diabetes mellitus	1.80	1.62e-2	42/46 (91.3%)	IRS2;PKM;MAPK1;...
Mismatch repair	1.79	1.78e-2	22/23 (95.65%)	RFC4;RPA1;MSH6;...
Tryptophan metabolism	1.78	1.83e-2	35/42 (83.33%)	DLD;MAOA;CYP1B1;...
Cholinergic synapse	1.77	1.78e-2	99/113 (87.61%)	CREB1;PRKCA;ITPR1;...
Glycine, serine and threonine metabolism	1.77	1.90e-2	31/40 (77.5%)	DLD;PGAM1;MAOA;...
Carbohydrate digestion and absorption	1.76	1.86e-2	37/47 (78.72%)	FXYD2;SLC2A5;PRKCB;...
Glutamatergic synapse	1.66	4.93e-2	97/114 (85.09%)	PRKCA;ITPR1;PRKACB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼