Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNRP2L)

• Drug Name: GSK-650394 Drug Info
• Synonyms: SGK-1 inhibitor (prostate cancer), GlaxoSmithKline
• Cross-matching ID:
  PubChem CID: 25022668
  ChEBI ID: CHEMBL558642
  CAS Number: CAS 890842-28-1
  TTD Drug ID: D0F3FC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.12	0.00e+0	34/36 (94.44%)	PRIM1;POLE2;DNA2;...
One carbon pool by folate	2.01	8.97e-3	15/20 (75%)	MTHFD2;MTHFD1;TYMS;...
Fanconi anemia pathway	1.95	1.20e-2	36/54 (66.67%)	BRCA1;RAD51;USP1;...
Endocrine and other factor-regulated calcium reabsorpti...	1.77	4.30e-2	49/53 (92.45%)	ATP1A1;PRKCB;ATP1B3;...
Protein export	1.77	3.59e-2	17/23 (73.91%)	SEC61B;SRPRB;SPCS1;...
Peroxisome	-1.80	2.89e-2	72/82 (87.8%)	ACSL3;HAO1;IDH1;...
Terpenoid backbone biosynthesis	-1.82	3.79e-2	18/22 (81.82%)	MVK;HMGCS2;MVD;...
Steroid biosynthesis	-2.37	0.00e+0	19/20 (95%)	EBP;HSD17B7;FDFT1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
VCaP	CVCL_2235	Homo sapiens	0.37uM - 10uM	6H, 24H	Hide ▲