Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNSJ7V)

Drug Name
Tropisetron Drug Info
Synonyms
Navoban; Novaban; TKT; ICS-205930; Navoban (TN); Tropisetron (INN); [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
Cross-matching ID
PubChem CID
656665
ChEBI ID
CHEMBL32269
CAS Number
CAS 89565-68-4
TTD Drug ID
D0K0KH
INTEDE Drug ID
DR1653

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 1.80 3.75e-2 66/74 (89.19%) LPL;SORBS1;FABP5;...
Ribosome biogenesis in eukaryotes 1.79 3.75e-2 52/108 (48.15%) PWP2;NHP2;RPP38;...
Selenocompound metabolism -1.73 3.94e-2 11/17 (64.71%) SCLY;SEPHS2;TXNRD1;...
Ferroptosis -1.82 1.41e-2 36/41 (87.8%) TF;ACSL4;PCBP2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.82 1.48e-2 62/70 (88.57%) NOD1;MAP2K4;CHUK;...
Other glycan degradation -1.83 1.59e-2 13/18 (72.22%) GLB1;HEXB;MANBA;...
Collecting duct acid secretion -1.83 2.12e-2 22/27 (81.48%) ATP4B;ATP6V0E2;ATP4A;...
Rheumatoid arthritis -1.85 1.59e-2 78/93 (83.87%) TNFSF13;JUN;TCIRG1;...
Steroid hormone biosynthesis -1.93 1.06e-2 43/61 (70.49%) CYP11A1;CYP7A1;HSD11B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM - 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H