Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNSJFD)

• Drug Name: INDORAMIN Drug Info
• Synonyms: INDORAMIN; Indoramine; 26844-12-2; Indoramina; Wy-21901; Indoraminum [INN-Latin]; Indoramine [INN-French]; Indoramina [INN-Spanish]; UNII-0Z802HMY7H; Baratol; EINECS 248-041-5; BRN 0494035; WY 21901; 0Z802HMY7H; CHEMBL279516; C22H25N3O; Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-; 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole; JXZZEXZZKAWDSP-UHFFFAOYSA-N; N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide; N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide; Benzamide, N-(1-(2-indol-3-ylethyl)-4-piperidyl)-; Benzamide, N
• Cross-matching ID:
  PubChem CID: 33625
  ChEBI ID: CHEMBL279516
  CAS Number: CAS 26844-12-2
  TTD Drug ID: D02LHR
  INTEDE Drug ID: DR0876

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
T cell receptor signaling pathway	1.96	3.54e-2	93/104 (89.42%)	MAPK13;LCP2;RASGRP1;...
Malaria	-1.67	3.68e-2	44/50 (88%)	SELE;TLR4;KLRB1;...
Arginine biosynthesis	-1.67	3.94e-2	17/22 (77.27%)	ASL;GLUD1;GOT2;...
Prion disease	-1.69	3.21e-2	209/273 (76.56%)	COX6A1;PPIF;CASP3;...
Parkinson disease	-1.72	2.51e-2	176/249 (70.68%)	COX7C;VDAC3;BCL2L1;...
Glycine, serine and threonine metabolism	-1.76	1.82e-2	31/40 (77.5%)	GLDC;SHMT1;AGXT;...
Linoleic acid metabolism	-1.76	1.84e-2	21/29 (72.41%)	CYP2E1;CYP1A2;PLA2G4C;...
RNA degradation	-1.82	1.11e-2	53/79 (67.09%)	CNOT7;EDC3;MPHOSPH6;...
Ribosome	-1.82	1.15e-2	113/158 (71.52%)	RPL14;RPS15;RPS4X;...
Oxidative phosphorylation	-1.83	1.19e-2	93/133 (69.92%)	NDUFA1;ATP6V1B1;TCIRG1;...
Porphyrin and chlorophyll metabolism	-1.87	8.36e-3	23/43 (53.49%)	BLVRB;CPOX;UGT2B4;...
Retinol metabolism	-1.89	1.00e-2	41/68 (60.29%)	UGT2B4;CYP1A1;CYP26B1;...
Proteasome	-1.95	6.27e-3	44/46 (95.65%)	PSMB4;PSMA4;PSMB8;...
Legionellosis	-1.98	5.57e-3	51/57 (89.47%)	C3;HSPA2;TLR4;...
Steroid hormone biosynthesis	-1.98	8.36e-3	43/61 (70.49%)	UGT2B4;CYP1A1;AKR1C2;...
Staphylococcus aureus infection	-2.05	8.36e-3	72/95 (75.79%)	HLA-DOB;KRT16;FPR1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 3.33uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼