Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNTQL5)

• Drug Name: PMID28270010-Compound-Figure24-a Drug Info
• Cross-matching ID:
  PubChem CID: 11617559
  ChEBI ID: CHEMBL261849
  CAS Number: CAS 870483-87-7
  TTD Drug ID: D0X9VS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Rheumatoid arthritis	2.04	0.00e+0	78/93 (83.87%)	CXCL8;CXCL2;VEGFA;...
Legionellosis	1.89	2.07e-2	51/57 (89.47%)	CXCL8;CXCL2;CASP1;...
Antigen processing and presentation	1.83	2.48e-2	60/78 (76.92%)	CTSS;CD74;HLA-DRA;...
Ubiquinone and other terpenoid-quinone biosynthesis	1.77	3.93e-2	9/11 (81.82%)	HPD;VKORC1;COQ2;...
Caffeine metabolism	1.76	3.14e-2	5/6 (83.33%)	NAT1;CYP2A6;NAT2;...
Endocrine and other factor-regulated calcium reabsorpti...	-1.76	4.48e-2	49/53 (92.45%)	ATP1B3;CLTCL1;ATP2B4;...
Carbohydrate digestion and absorption	-1.79	3.62e-2	37/47 (78.72%)	ATP1A2;HK1;AKT3;...
Glycerolipid metabolism	-1.80	4.34e-2	44/61 (72.13%)	LIPF;DGKZ;DGAT1;...
Type II diabetes mellitus	-1.89	2.41e-2	42/46 (91.3%)	HK1;IKBKB;SOCS1;...
Insulin secretion	-1.92	1.21e-2	75/86 (87.21%)	PLCB4;ATP1A3;CACNA1D;...
Phosphatidylinositol signaling system	-2.06	1.21e-2	82/97 (84.54%)	PIK3CB;IP6K1;PLCG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲