Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNWIYM)

Drug Name
Flavanone Drug Info
Synonyms
FLAVANONE; 487-26-3; 2-Phenylchroman-4-one; 2,3-Dihydroflavone; 2-Phenyl-4-chromanone; 4-Flavanone; 2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-2-phenyl-; 2-Phenyl-2,3-dihydro-4H-chromen-4-one; NSC-50393; 2,3-Dihydro-2-phenyl-4H-benzopyran-4-one; 2-Phenyl-chroman-4-one; 2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one; EINECS 207-654-8; NSC 50393; BRN 0183227; MLS002667384; CHEMBL274318; CHEBI:5070; ZONYXWQDUYMKFB-UHFFFAOYSA-N; NSC50393; 2-phenyl-2,3-dihydrochromen-4-one; MFCD00006841; (-)-Flavanone
Cross-matching ID
PubChem CID
10251
ChEBI ID
CHEMBL274318
CAS Number
CAS 487-26-3
TTD Drug ID
D0B4VE
INTEDE Drug ID
DR2357

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nucleotide excision repair 2.06 0.00e+0 40/47 (85.11%) GTF2H4;RAD23A;RAD23B;...
Ribosome 2.05 4.57e-3 113/158 (71.52%) MRPL11;RPS26;RPL36;...
Proximal tubule bicarbonate reclamation 2.00 1.22e-2 21/23 (91.3%) CA2;AQP1;GLUD2;...
Nitrogen metabolism 1.87 2.29e-2 16/17 (94.12%) CA2;GLUD2;GLUD1;...
Mismatch repair 1.81 3.29e-2 22/23 (95.65%) MSH2;RPA3;RFC2;...
Non-homologous end-joining 1.81 2.74e-2 11/13 (84.62%) DNTT;DCLRE1C;XRCC5;...
Proteasome 1.81 2.35e-2 44/46 (95.65%) PSMD11;PSMA1;PSMA7;...
Spliceosome 1.72 4.23e-2 101/150 (67.33%) LSM5;HSPA8;SNRPG;...
DNA replication 1.72 3.86e-2 34/36 (94.44%) PRIM1;RPA3;RFC2;...
TNF signaling pathway -1.92 1.43e-2 103/112 (91.96%) FOS;CSF1;CX3CL1;...
Staphylococcus aureus infection -1.95 1.07e-2 72/95 (75.79%) C1QB;CFI;C1QA;...
Mineral absorption -2.19 1.07e-2 48/60 (80%) STEAP1;SLC8A1;SLC31A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H