General Information of Drug (ID: DMNXDGQ)

Drug Name
NSC-1771 Drug Info
Synonyms Thiram
Cross-matching ID
PubChem CID
5455
ChEBI ID
CHEMBL120563
CAS Number
CAS 137-26-8
TTD Drug ID
D02UVS
INTEDE Drug ID
DR1585

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.17 0.00e+0 101/150 (67.33%) HSPA1A;HSPA6;SF3A2;...
Proteasome 2.07 0.00e+0 44/46 (95.65%) PSMC4;ADRM1;PSMD13;...
Ribosome biogenesis in eukaryotes 1.91 1.79e-2 52/108 (48.15%) LSG1;NVL;GNL2;...
IL-17 signaling pathway 1.89 2.46e-2 84/94 (89.36%) FOS;CXCL2;FOSB;...
Rheumatoid arthritis 1.87 2.15e-2 78/93 (83.87%) FOS;CXCL2;MMP1;...
Legionellosis 1.86 1.94e-2 51/57 (89.47%) HSPA1A;HSPA6;CXCL2;...
Mineral absorption 1.85 1.79e-2 48/60 (80%) MT1E;MT1F;MT1M;...
RNA polymerase 1.82 2.01e-2 23/31 (74.19%) POLR2I;POLR3E;POLR3G;...
MAPK signaling pathway 1.78 2.59e-2 272/294 (92.52%) HSPA1A;GADD45B;HSPA6;...
Epithelial cell signaling in Helicobacter pylori infect... 1.78 2.42e-2 62/70 (88.57%) CXCL2;JUN;MET;...
NF-kappa B signaling pathway 1.73 4.07e-2 90/104 (86.54%) GADD45B;CXCL2;RELB;...
Diabetic cardiomyopathy -1.58 4.85e-2 162/203 (79.8%) PPARA;PLCB2;COX7A2L;...
Arginine and proline metabolism -1.58 4.86e-2 39/50 (78%) CKMT2;ARG2;ALDH9A1;...
Terpenoid backbone biosynthesis -1.58 4.99e-2 18/22 (81.82%) GGPS1;IDI1;ICMT;...
Primary bile acid biosynthesis -1.60 4.39e-2 15/17 (88.24%) SCP2;CYP46A1;HSD17B4;...
beta-Alanine metabolism -1.64 3.42e-2 25/30 (83.33%) GAD2;EHHADH;ALDH9A1;...
Drug metabolism -1.64 3.42e-2 78/151 (51.66%) GSTP1;ADH7;UMPS;...
Thyroid hormone synthesis -1.64 3.56e-2 66/75 (88%) GPX1;HSP90B1;ASGR2;...
Nitrogen metabolism -1.67 2.82e-2 16/17 (94.12%) GLUD2;GLUL;GLUD1;...
Butanoate metabolism -1.68 2.69e-2 23/28 (82.14%) ECHS1;ACAT2;HMGCS1;...
Alanine, aspartate and glutamate metabolism -1.69 2.66e-2 27/37 (72.97%) GPT;GLUD2;GLUL;...
Arachidonic acid metabolism -1.69 2.56e-2 48/61 (78.69%) CYP4F3;GPX1;ALOX5;...
Glutathione metabolism -1.72 1.92e-2 43/57 (75.44%) IDH2;GSTM1;PRDX6;...
Steroid hormone biosynthesis -1.73 1.84e-2 43/61 (70.49%) SULT2B1;HSD17B1;HSD17B3;...
Pentose and glucuronate interconversions -1.73 1.88e-2 17/34 (50%) XYLB;AKR1A1;KL;...
Glycosphingolipid biosynthesis -1.73 1.85e-2 37/57 (64.91%) FUT3;B3GALT4;ST8SIA1;...
Fatty acid elongation -1.78 1.14e-2 19/27 (70.37%) HSD17B12;ACOT7;ELOVL6;...
Glyoxylate and dicarboxylate metabolism -1.79 1.22e-2 23/30 (76.67%) PCCA;AGXT;DLD;...
Propanoate metabolism -1.86 3.51e-3 30/34 (88.24%) EHHADH;DLD;ACOX1;...
Fatty acid degradation -1.88 1.90e-3 40/43 (93.02%) ACSL3;ACSL4;EHHADH;...
Steroid biosynthesis -1.90 2.07e-3 19/20 (95%) FDFT1;LSS;LBR;...
Peroxisome -1.90 1.14e-3 72/82 (87.8%) PEX12;PEX19;DECR2;...
Pyruvate metabolism -1.90 1.27e-3 41/47 (87.23%) GLO1;AKR1A1;FH;...
Valine, leucine and isoleucine degradation -1.91 1.42e-3 42/48 (87.5%) BCKDHB;ACADSB;ALDH1B1;...
Phenylalanine metabolism -1.92 1.63e-3 14/17 (82.35%) ALDH3A1;PAH;MAOA;...
Ascorbate and aldarate metabolism -1.93 1.90e-3 15/30 (50%) AKR1A1;ALDH9A1;KL;...
Citrate cycle (TCA cycle) -1.99 0.00e+0 30/30 (100%) FH;IDH2;DLD;...
Biosynthesis of unsaturated fatty acids -2.05 0.00e+0 21/27 (77.78%) SCP2;HSD17B12;SCD;...
Histidine metabolism -2.15 0.00e+0 16/22 (72.73%) ALDH1B1;FTCD;ALDH2;...
Tryptophan metabolism -2.15 0.00e+0 35/42 (83.33%) KYAT1;EHHADH;ALDH9A1;...
Metabolism of xenobiotics by cytochrome P450 -2.29 0.00e+0 49/77 (63.64%) GSTM1;AKR7A2;GSTP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM - 40uM 3H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.08uM - 20uM 24H