Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMNXYSM)

Drug Name
gingerol Drug Info
Synonyms [6]-Gingerol; 6-Gingerol
Cross-matching ID
PubChem CID
442793
ChEBI ID
CHEMBL402978
CAS Number
CAS 23513-14-6
TTD Drug ID
D0Y1YR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.11 0.00e+0 34/36 (94.44%) PCNA;RFC2;FEN1;...
Nucleotide excision repair 1.87 2.01e-2 40/47 (85.11%) RAD23B;PCNA;RFC2;...
Drug metabolism 1.85 1.67e-2 78/151 (51.66%) GSTT1;ADH1B;HPRT1;...
Retinol metabolism 1.84 1.50e-2 41/68 (60.29%) ADH1B;CYP26B1;AOX1;...
Nitrogen metabolism 1.80 2.41e-2 16/17 (94.12%) CA2;CA4;CA12;...
Epithelial cell signaling in Helicobacter pylori infect... 1.80 2.01e-2 62/70 (88.57%) PAK1;ATP6V1D;PTPRZ1;...
Mismatch repair 1.77 2.44e-2 22/23 (95.65%) PCNA;RFC2;LIG1;...
Asthma -1.77 4.39e-2 25/31 (80.65%) HLA-DRA;HLA-DPB1;HLA-DPA1;...
Staphylococcus aureus infection -1.81 3.74e-2 72/95 (75.79%) HLA-DRA;C1S;KRT19;...
Systemic lupus erythematosus -1.85 2.66e-2 45/135 (33.33%) HLA-DRA;C1S;C1QA;...
Antigen processing and presentation -1.99 9.97e-3 60/78 (76.92%) TAPBP;HSPA4;HLA-DPA1;...
Steroid biosynthesis -2.10 9.97e-3 19/20 (95%) CYP51A1;MSMO1;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H